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MCB：去甲基化酶LSD2抑制肝脏细胞脂代谢

2015-02-04 佚名 生物谷

肝脏代谢
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近日，来自日本的科学家在国际生物学期刊Molecular and Cellular Biology在线发表了他们的最新研究进展，他们发现赖氨酸特异性去甲基化酶LSD2能够抑制肝脏细胞中脂质交换与代谢，以维持肝脏细胞的能量平衡。这一研究结果对阐述表观遗传与代谢平衡的关系具有比较重要的意义。 研究人员指出，细胞能够将环境波动如营养变化与代谢重塑过程联系起来，普遍认为表观遗传调控因子在这一过程中起到比

近日，来自日本的科学家在国际生物学期刊Molecular and Cellular Biology在线发表了他们的最新研究进展，他们发现赖氨酸特异性去甲基化酶LSD2能够抑制肝脏细胞中脂质交换与代谢，以维持肝脏细胞的能量平衡。这一研究结果对阐述表观遗传与代谢平衡的关系具有比较重要的意义。

研究人员指出，细胞能够将环境波动如营养变化与代谢重塑过程联系起来，普遍认为表观遗传调控因子在这一过程中起到比较重要的作用，但具体分子机制仍不是特别清楚。Katsuya Nagaoka等人发现赖氨酸特异性去甲基化酶LSD2能够抑制肝脏细胞中脂质交换与代谢过程，通过对转录组和CHIP-sequencing进行分析，研究人员证实LSD2能够通过对组蛋白H3K4进行去甲基化抑制脂质交换和代谢相关基因表达。
 
同时研究人员还发现转录因子c-jun能够部分调控LSD2招募到脂代谢相关基因位点的过程。更为有趣的是，对LSD2缺失细胞进行脂肪酸刺激，细胞内许多代谢中间产物的水平都会增加，同时伴随对细胞毒性损伤的易感性增加。
 
综上所述，该文章发现在营养环境波动的情况下，肝脏细胞内的赖氨酸特异性去甲基化酶LSD2能够维持肝脏细胞脂质代谢平衡，并且通过实验证明，这种作用主要是通过调控表观遗传与代谢之间的相互作用来实现的。这对阐述表观遗传与代谢之间的关系具有一定意义。（生物谷Bioon.com）

原始出处

Nagaoka K1, Hino S2, Sakamoto A3, Anan K3, Takase R3, Umehara T4, Yokoyama S4, Sasaki Y5, Nakao M6.Lysine-specific demethylase LSD2 suppresses lipid influx and metabolism in hepatic cells.Mol Cell Biol. 2015 Jan 26.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1735737, encodeId=e21b1e35737d8, content=<a href='/topic/show?id=9c363e259ba' target=_blank style='color:#2F92EE;'>#去甲基化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37259, encryptionId=9c363e259ba, topicName=去甲基化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=031d33977719, createdName=AspirantSuo, createdTime=Thu May 14 06:12:00 CST 2015, time=2015-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798660, encodeId=10621e98660f9, content=<a href='/topic/show?id=169069e8530' target=_blank style='color:#2F92EE;'>#甲基化酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69785, encryptionId=169069e8530, topicName=甲基化酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=af60254, createdName=mhm289, createdTime=Wed Sep 30 06:12:00 CST 2015, time=2015-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684225, encodeId=a47d16842250c, content=<a href='/topic/show?id=781d81464d1' target=_blank style='color:#2F92EE;'>#肝脏细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81464, encryptionId=781d81464d1, topicName=肝脏细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3da28060610, createdName=wgx315, createdTime=Tue Aug 18 02:12:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17548, encodeId=fb491e5485b, content=超赞，好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Wed Mar 04 10:46:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597058, encodeId=2114159e05858, content=<a href='/topic/show?id=e7f6842982d' target=_blank style='color:#2F92EE;'>#脂代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84298, encryptionId=e7f6842982d, topicName=脂代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce3218475330, createdName=huangdf, createdTime=Fri Feb 06 00:12:00 CST 2015, time=2015-02-06, status=1, ipAttribution=)]
    2015-05-14 AspirantSuo

    #去甲基化#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1735737, encodeId=e21b1e35737d8, content=<a href='/topic/show?id=9c363e259ba' target=_blank style='color:#2F92EE;'>#去甲基化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37259, encryptionId=9c363e259ba, topicName=去甲基化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=031d33977719, createdName=AspirantSuo, createdTime=Thu May 14 06:12:00 CST 2015, time=2015-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798660, encodeId=10621e98660f9, content=<a href='/topic/show?id=169069e8530' target=_blank style='color:#2F92EE;'>#甲基化酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69785, encryptionId=169069e8530, topicName=甲基化酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=af60254, createdName=mhm289, createdTime=Wed Sep 30 06:12:00 CST 2015, time=2015-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684225, encodeId=a47d16842250c, content=<a href='/topic/show?id=781d81464d1' target=_blank style='color:#2F92EE;'>#肝脏细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81464, encryptionId=781d81464d1, topicName=肝脏细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3da28060610, createdName=wgx315, createdTime=Tue Aug 18 02:12:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17548, encodeId=fb491e5485b, content=超赞，好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Wed Mar 04 10:46:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597058, encodeId=2114159e05858, content=<a href='/topic/show?id=e7f6842982d' target=_blank style='color:#2F92EE;'>#脂代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84298, encryptionId=e7f6842982d, topicName=脂代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce3218475330, createdName=huangdf, createdTime=Fri Feb 06 00:12:00 CST 2015, time=2015-02-06, status=1, ipAttribution=)]
    2015-09-30 mhm289

    #甲基化酶#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1735737, encodeId=e21b1e35737d8, content=<a href='/topic/show?id=9c363e259ba' target=_blank style='color:#2F92EE;'>#去甲基化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37259, encryptionId=9c363e259ba, topicName=去甲基化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=031d33977719, createdName=AspirantSuo, createdTime=Thu May 14 06:12:00 CST 2015, time=2015-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798660, encodeId=10621e98660f9, content=<a href='/topic/show?id=169069e8530' target=_blank style='color:#2F92EE;'>#甲基化酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69785, encryptionId=169069e8530, topicName=甲基化酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=af60254, createdName=mhm289, createdTime=Wed Sep 30 06:12:00 CST 2015, time=2015-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684225, encodeId=a47d16842250c, content=<a href='/topic/show?id=781d81464d1' target=_blank style='color:#2F92EE;'>#肝脏细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81464, encryptionId=781d81464d1, topicName=肝脏细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3da28060610, createdName=wgx315, createdTime=Tue Aug 18 02:12:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17548, encodeId=fb491e5485b, content=超赞，好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Wed Mar 04 10:46:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597058, encodeId=2114159e05858, content=<a href='/topic/show?id=e7f6842982d' target=_blank style='color:#2F92EE;'>#脂代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84298, encryptionId=e7f6842982d, topicName=脂代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce3218475330, createdName=huangdf, createdTime=Fri Feb 06 00:12:00 CST 2015, time=2015-02-06, status=1, ipAttribution=)]
    2015-08-18 wgx315

    #肝脏细胞#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1735737, encodeId=e21b1e35737d8, content=<a href='/topic/show?id=9c363e259ba' target=_blank style='color:#2F92EE;'>#去甲基化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37259, encryptionId=9c363e259ba, topicName=去甲基化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=031d33977719, createdName=AspirantSuo, createdTime=Thu May 14 06:12:00 CST 2015, time=2015-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798660, encodeId=10621e98660f9, content=<a href='/topic/show?id=169069e8530' target=_blank style='color:#2F92EE;'>#甲基化酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69785, encryptionId=169069e8530, topicName=甲基化酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=af60254, createdName=mhm289, createdTime=Wed Sep 30 06:12:00 CST 2015, time=2015-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684225, encodeId=a47d16842250c, content=<a href='/topic/show?id=781d81464d1' target=_blank style='color:#2F92EE;'>#肝脏细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81464, encryptionId=781d81464d1, topicName=肝脏细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3da28060610, createdName=wgx315, createdTime=Tue Aug 18 02:12:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17548, encodeId=fb491e5485b, content=超赞，好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Wed Mar 04 10:46:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597058, encodeId=2114159e05858, content=<a href='/topic/show?id=e7f6842982d' target=_blank style='color:#2F92EE;'>#脂代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84298, encryptionId=e7f6842982d, topicName=脂代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce3218475330, createdName=huangdf, createdTime=Fri Feb 06 00:12:00 CST 2015, time=2015-02-06, status=1, ipAttribution=)]
    2015-03-04 xiaoai5777

    超赞，好文章

    0

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    2015-02-06 huangdf

    #脂代谢#

    0

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