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Diabetes Care:夜间低血糖会影响睡眠时觉醒功能

2015-10-25 Seven L 译 MedSci原创

研究者进行了一项试验探究夜间低血糖对睡眠和相关激素的影响,研究者根据多导睡眠图评估参与者的睡眠情况。该单盲交叉研究共纳入26名2型糖尿病患者,分别在正常血糖(5.0-7.0 mmol/L )和低血糖(2.7-2.8 mmol/L )情况下经历睡眠,两种情况的先后经历是随机的。研究结果显示,在睡眠的前4个小时(睡眠状态N2后0-4h),两组间脑电图提示的微觉醒和觉醒频率没有差异,不过在4-8小时低血

研究者进行了一项试验探究夜间低血糖对睡眠和相关激素的影响,研究者根据多导睡眠图评估参与者的睡眠情况。

该单盲交叉研究共纳入26名2型糖尿病患者,分别在正常血糖(5.0-7.0 mmol/L )和低血糖(2.7-2.8 mmol/L )情况下经历睡眠,两种情况的先后经历是随机的。

研究结果显示,在睡眠的前4个小时(睡眠状态N2后0-4h),两组间脑电图提示的微觉醒和觉醒频率没有差异,不过在4-8小时,低血糖组觉醒频率比正常血糖组低了27%,按0-8小时算,则低了有20%。并且研究者还观察到,低血糖组比正常血糖组有睡眠更长时间的趋势(366 vs. 349 min)。相关激素(肾上腺素、生长激素和皮质醇)在低血糖组也更高,据统计学意义。

研究结果表明,2型糖尿病患者夜间低血糖会使其在4-8小时的睡眠阶段觉醒次数更少。该发现强调了夜间低血糖的风险,因为夜间低血糖可能潜在的影响患者觉醒功能,以及对足够碳水化合物摄入的反应情况。

原始出处:

Jennum P, Stender-Petersen K,et al.The Impact of Nocturnal Hypoglycemia on Sleep in Subjects With Type 2 Diabetes.Diabetes Care. 2015 Nov;38(11):2151-7.


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    2016-07-12 guoyibin
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    2015-10-26 miaotao

    例数好少,设计很重要

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1637185, encodeId=b5c0163e1858e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Jul 24 21:33:00 CST 2016, time=2016-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645356, encodeId=2a37164535616, content=<a href='/topic/show?id=adfe9090e2b' target=_blank style='color:#2F92EE;'>#觉醒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90907, encryptionId=adfe9090e2b, topicName=觉醒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=36f323200284, createdName=guoyibin, createdTime=Tue Jul 12 17:33:00 CST 2016, time=2016-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901321, encodeId=20361901321e3, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri Aug 19 09:33:00 CST 2016, time=2016-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759601, encodeId=16431e596012d, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Aug 20 00:33:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41380, encodeId=8bb441380b8, content=例数好少,设计很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=77e41648823, createdName=miaotao, createdTime=Mon Oct 26 19:09:00 CST 2015, time=2015-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41317, encodeId=611f4131e63, content=不知道长期影响如何, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Mon Oct 26 11:19:00 CST 2015, time=2015-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41301, encodeId=1f2141301d9, content=最近老是睡不醒的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150830/IMG55E294026A9942981.jpg, createdBy=fa351627501, createdName=惜言, createdTime=Mon Oct 26 10:21:00 CST 2015, time=2015-10-26, status=1, ipAttribution=)]
    2015-10-26 lixh1719

    不知道长期影响如何

    0

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    2015-10-26 惜言

    最近老是睡不醒的感觉

    0

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