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Int J Cancer:胎次、母乳喂养影响卵巢癌患者的组织学亚型(前瞻性研究)

2017-09-27 MedSci MedSci原创

众所周知,在有孩子的妇女中卵巢癌的发病率有所下降,但母乳喂养与卵巢癌发病率的相关性却不尽相同。来自英国的研究人员认为,根据组织学类型,一些研究能可靠地探索二者之间的相关性。在一项纳入110万名英国妇女的前瞻性研究中,随访期间有8719名妇女进展为卵巢癌。调整不同生育模式的妇女的肿瘤组织学类型,研究人员采用Cox回归分析得到了调整后的整体相对风险(RR)。研究人员发现,初产妇比有一个孩子的妇女的卵巢

众所周知,在有孩子的妇女中卵巢癌的发病率有所下降,但母乳喂养与卵巢癌发病率的相关性却不尽相同。来自英国的研究人员认为,根据组织学类型,一些研究能可靠地探索二者之间的相关性。在一项纳入110万名英国妇女的前瞻性研究中,随访期间有8719名妇女进展为卵巢癌。调整不同生育模式的妇女的肿瘤组织学类型,研究人员采用Cox回归分析得到了调整后的整体相对风险(RR)。研究人员发现,初产妇比有一个孩子的妇女的卵巢癌风险高了24%以上,且她们组织学类型的异质性显著(P = 0.01)。浆液性肿瘤患者的卵巢癌风险无明显增加,粘液性肿瘤患者的卵巢癌风险有适度增加,子宫内膜样肿瘤和透明细胞癌患者的风险却大幅增加(分别为,RR = 1.49,95%置信区间:1.18-1.89;RR = 1.68,95%CI,1.29-2.20)。经产妇中,每多生产一次,则卵巢癌风险整体降低6%;组织学类型也存在相关性变化(P = 0.0006),且在透明细胞肿瘤中风险降低最大(每生产一次的RR= 0.75,P<0.001 0.65-0.85,),但对子宫内膜样肿瘤、程度较高的浆液性或粘液性肿瘤的影响几近于无。研究人员还发现,第

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  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/07/8c1e5a0085f3b74f3a4ab58a38a3d487.jpg, createdBy=b33e2159612, createdName=2227437833_79976374, createdTime=Fri Sep 29 18:30:51 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299568, encodeId=85ec129956815, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Fri Sep 29 14:46:00 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248425, encodeId=d93524842538, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Sep 28 07:00:32 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248347, encodeId=644324834e1a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu Sep 28 00:49:30 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248321, encodeId=afd4248321b4, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Thu Sep 28 00:04:41 CST 2017, time=2017-09-28, status=1, ipAttribution=)]
    2017-10-05 131****1460

    学习了受益匪浅

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/07/8c1e5a0085f3b74f3a4ab58a38a3d487.jpg, createdBy=b33e2159612, createdName=2227437833_79976374, createdTime=Fri Sep 29 18:30:51 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299568, encodeId=85ec129956815, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Fri Sep 29 14:46:00 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248425, encodeId=d93524842538, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Sep 28 07:00:32 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248347, encodeId=644324834e1a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu Sep 28 00:49:30 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248321, encodeId=afd4248321b4, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Thu Sep 28 00:04:41 CST 2017, time=2017-09-28, status=1, ipAttribution=)]
    2017-09-29 2227437833_79976374

    哈哈哈还好还好

    0

  7. 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channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Sep 28 07:00:32 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248347, encodeId=644324834e1a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu Sep 28 00:49:30 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248321, encodeId=afd4248321b4, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Thu Sep 28 00:04:41 CST 2017, time=2017-09-28, status=1, ipAttribution=)]
    2017-09-29 villahu
  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Thu Sep 28 00:04:41 CST 2017, time=2017-09-28, status=1, ipAttribution=)]
    2017-09-28 明月清辉

    谢谢分享.学习了

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/07/8c1e5a0085f3b74f3a4ab58a38a3d487.jpg, createdBy=b33e2159612, createdName=2227437833_79976374, createdTime=Fri Sep 29 18:30:51 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299568, encodeId=85ec129956815, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Fri Sep 29 14:46:00 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248425, encodeId=d93524842538, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Sep 28 07:00:32 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248347, encodeId=644324834e1a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu Sep 28 00:49:30 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248321, encodeId=afd4248321b4, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Thu Sep 28 00:04:41 CST 2017, time=2017-09-28, status=1, ipAttribution=)]
    2017-09-28 yfjms

    学习了

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Thu Sep 28 00:04:41 CST 2017, time=2017-09-28, status=1, ipAttribution=)]
    2017-09-28 luominglian113

    学习了.谢谢分享

    0

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