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Obesity:代谢正常型肥胖也会增加糖尿病的发病风险,与非酒精性脂肪肝无关

2016-08-12 MedSci MedSci原创

近日,发表在Obesity的一项研究指出:代谢正常型肥胖也会增加糖尿病的发病风险,与非酒精性脂肪肝的存在与否无关,梅斯医学小编整理研究主要内容如下: 目的 本研究旨在通过大型队列研究来验证是否代谢正常型肥胖会增加糖尿病的发病危险,而无论其是否伴有非酒精性脂肪性肝病(NAFLD)。 方法 研究纳入74509 名基线时期代谢正常的成年人,代谢正常定义为,除外腰围较大外,无任

近日,发表在Obesity的一项研究指出:代谢正常型肥胖也会增加糖尿病的发病风险,与非酒精性脂肪肝的存在与否无关,梅斯医学小编整理研究主要内容如下:

目的

本研究旨在通过大型队列研究来验证是否代谢正常型肥胖会增加糖尿病的发病危险,而无论其是否伴有非酒精性脂肪性肝病(NAFLD)。

方法

研究纳入74509 名基线时期代谢正常的成年人,代谢正常定义为,除外腰围较大外,无任何代谢综合征表现,经过稳定模型评价胰岛素抵抗指数<2.5。NAFLD定义为在没有过度饮酒或者其他明确病因的情况下超声检查发现肝脂肪变性。

结果

随访超过304852.6 人年,472名参与者发展为糖尿病(发病率密度,1.5/1000人年)。校正混杂因素后,与正常体重相比,超重和肥胖参与者糖尿病的危险比(95%可信区间)分别为1.29(1.00-2.16)和1.57(1.14-2.16);与NAFLD患者相比,无NAFLD的参与者则分别为1.190(0.95-3.80)和2.57(1.32-5.02)(相关性P=2.57)。

结论

在代谢正常的人群中,超重和肥胖的个体其糖尿病的发病率增高,与NAFLD存在与否无关。该发现表明肥胖本身就会增加糖尿病的发病风险,与NAFLD无关。

原始出处:

Yoosoo Chang,Hyun-Suk Jung, et al., Metabolically healthy obesity is associated with an increased risk of diabetes independently of nonalcoholic fatty liver disease. Obesity. 2016;doi:10.1002/oby.21580.

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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 21:54:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461748, encodeId=a9091461e487a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Sun Aug 14 06:17:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588229, encodeId=76f91588229f5, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Sun Aug 14 06:17:00 CST 2016, time=2016-08-14, status=1, ipAttribution=)]
    2016-09-20 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

  5. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 21:54:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461748, encodeId=a9091461e487a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Sun Aug 14 06:17:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588229, encodeId=76f91588229f5, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Sun Aug 14 06:17:00 CST 2016, time=2016-08-14, status=1, ipAttribution=)]
    2016-09-12 舒心和人

    看了这么多资讯,越来越发现肥胖竟然如此可怕,再也不敢不控制体重了

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 21:54:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461748, encodeId=a9091461e487a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Sun Aug 14 06:17:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588229, encodeId=76f91588229f5, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Sun Aug 14 06:17:00 CST 2016, time=2016-08-14, status=1, ipAttribution=)]
    2017-03-17 智慧医人
  7. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 21:54:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461748, encodeId=a9091461e487a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Sun Aug 14 06:17:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588229, encodeId=76f91588229f5, content=<a 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    2016-08-16 忠诚向上

    好好学习一下

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 21:54:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461748, encodeId=a9091461e487a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Sun Aug 14 06:17:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588229, encodeId=76f91588229f5, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Sun Aug 14 06:17:00 CST 2016, time=2016-08-14, status=1, ipAttribution=)]
    2016-08-14 doctorJiangchao

    继续学习,

    0

  9. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Aug 14 21:54:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461748, encodeId=a9091461e487a, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Sun Aug 14 06:17:00 CST 2016, time=2016-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588229, encodeId=76f91588229f5, content=<a 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    2016-08-14 lingaifan
  10. 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    2016-08-14 skhzy

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有研究表明,阻塞性睡眠呼吸暂停和夜间低浓度氧气可导致氧化应激,这与成人非酒精性脂肪肝疾病(NAFLD)的进展相关联。根据肝病学杂志的一项新报告,目前研究人员已经确定,这些因素也可能是儿童从NAFLD进展到非酒精性脂肪性肝炎(NASH)的重要触发因素。非酒精性脂肪肝病(NAFLD)是多余的脂肪在喝很少或没有喝酒的人的肝细胞中积累。这是一种流行性疾病,全世界越来越多的的成人和儿童中患该疾病。据估计,该

BMC Med:这些过早死亡危险因素,你占几个?

目的:探究吸烟、高血压、肥胖、运动、酒精和饮食对过早死亡风险的影响。方法:对EPIC前瞻性队列研究的264906个欧洲成年人数据进行了分析,年龄40-70岁。使用灵活参数生存模型评估不同因素对过早死亡的影响,以及70岁前死亡的生存函数和归因分数(AF)。结果:70岁前有11930人死亡。下列因素的AF分别为:吸烟31%(95 % CI, 31-32 %)、不良饮食模式14 % (95 % CI,

J Clin Oncol:与普通人群相比,癌症幸存者的肥胖率增加更快

特定癌症诊断后的肥胖与癌症预后较差有关。在过去的二十年中,我们研究了美国癌症幸存者的肥胖率的趋势,并与那些没有癌症病史的成年人的肥胖率趋势进行了比较。 此以人群为基础的全国代表性的样本共纳入了参与1997-2014年全国健康访谈调查的538969名美国成年人,年龄为18-85岁,伴或不伴癌症病史。定义肥胖为非亚洲人体重指数≥30 kg/m2,亚洲人体重指数≥27.5 kg/m2。 结果

Lancet Diabetes Endocrinol:减肥APP有没有用?

目的:评估通过Facebook、移动应用程序、文本消息、电子邮件、网站和与健康教练进行技术介导的沟通(SMART干预)等方式的减肥干预2年效果如何。方法:平行组、随机、对照试验纳入了超重或肥胖大学生(年龄18-35岁),被随机分配(1:1)接受干预(SMART干预组)或保健和健康相关的一般信息(对照组)。24个月后参与者的体重作为主要结局,干预后6、12、18个月的体重作为次要结局。结果:在201

JCO:肥胖与蒽环霉素毒性有何关系?

研究人员通过进行研究后发现,乳腺癌患者的肥胖程度与蒽环霉素和曲妥珠单抗的毒性明显相关。Charles Guenancia博士指出,这项研究后的第一步是用数据确认超重和肥胖是蒽环霉素毒性的独立风险因素。他认为,如果前瞻性研究发现并不是由于其他因素导致肥胖患者较体形较瘦的患者出现并发症的发生率较高,则肥胖患者应配合做好心功能评估、随访调查和后续化疗。 7月26日临床肿瘤学杂志上发表的一篇文章中,Gue

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