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ATVB:高密度脂蛋白胆固醇和死亡率之间的U型关系!

2018-01-12 xing.T MedSci原创

由此可见,在大型一般人群中可以观察到HDL-C与死亡率之间存在“U”型关系。

近日,心血管领域权威杂志Arteriosclerosis, Thrombosis, and Vascular Biology上发表了一篇研究文章,研究人员的目的是评估大样本人群中高密度脂蛋白胆固醇(HDL-C)与死亡率之间的关系。

研究人员从一般人群家庭调查(英格兰健康调查和苏格兰健康调查)中招募了成年参与者(n=37059,年龄为57.7±11.9岁,46.8%为男性)。个人参与者的数据与英国国家卫生服务中心登记中心进行联系,以记录死亡率。

在326016人次每年的随访中,有2250人死于各种原因。当与参考组(HDL-C为1.5-1.99mmol/L)相比,与全因死亡率可见明显的U型关联,在HDL-C浓度最低(风险比为1.23,95%可信区间为1.06-1.44)和浓度最高(1.25,0.97-1.62)的参与者中全因死亡风险增加。心血管疾病的相关性呈线性关系,HDL-C浓度最低者心血管疾病的风险升高(1.49,1.15-1.94)。

由此可见,在大型一般人群中可以观察到HDL-C与死亡率之间存在“U”型关系。

原始出处:

Mark Hamer,,et al. High-Density Lipoprotein Cholesterol and Mortality Too Much of a Good Thing?ATVB.2018.https://doi.org/10.1161/ATVBAHA.117.310587

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    2018-08-22 gongliu
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    2018-01-14 lofter

    学习了感谢分享

    0

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  5. 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    2018-01-13 天地飞扬

    学习一下.谢谢分享!

    0

  6. 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    2018-01-12 龙胆草

    学习谢谢分享

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Fri Jan 12 07:23:11 CST 2018, time=2018-01-12, status=1, ipAttribution=)]
    2018-01-12 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Fri Jan 12 07:23:11 CST 2018, time=2018-01-12, status=1, ipAttribution=)]
    2018-01-12 明月清辉

    谢谢分享.学习了

    0

  9. 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    2018-01-12 happsf

    学习

    0

  10. 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    2018-01-12 雾夜芭蕾

    内部的关系比较重要

    0

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烟酸,可有效提高HDL-C,或许能够减少动脉粥样硬化性心血管疾病患者或高危人群的心脏事件。然而,既往近期的两项大型随机对照试验,在他汀类药物治疗背景下,比较烟酸和安慰剂,却没有得出积极效果。 根据现有证据,我们研究了当前实践中,烟酸治疗降低心血管事件风险的作用。 在MEDLINE、EMBASE、CINAHL和Cochrane数据库中检索比较单独烟酸治疗或烟酸联合他汀类药物治疗的随机对照

SCI REP:HDL-C水平降低是急性胰腺炎患者预后的独立危险因素!

由此可见,降低的HDL-C水平是AP患者发生POF、PNec和住院死亡率的一个独立危险因素。

Eur J Neurol:维生素D缺乏与低HDL-C的卒中患者预后不良相关

背景:目前的观察研究表明,较低的维生素D水平与缺血性脑卒中较差预后风险较高相关。这种相关性是否受血脂水平的影响还不清楚。研究者旨在调查血清维生素D,尤其是维生素D的缺乏对不同血脂水平的缺血性卒中预后的影响。方法:中国急性缺血性脑卒中的降压试验中纳入3181例缺血性患者,检测患者基线血清25 -羟维生素D水平。前瞻性地随访急性缺血性卒中后3个月患者死亡,主要的残疾和血管事件的发生。应用多变量logi

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