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JAMA Pediatr:新生儿术前贫血可显著增加其术后死亡率

2016-10-27 MedSci MedSci原创

据发表于JAMA Pediatric的一项新的研究显示,新生儿心脏手术前贫血与其术后死亡率的增加相关。术前贫血是导致成人术后死亡的一个强有力的独立危险因素,但是在新生儿中是否也由此关系则尚未可知。研究采用回顾性分析设计,使用来自美国外科学会国家外科质量改进计划的2012年和2013年的儿童数据库的数据。记录所有新生儿(0-30天)术前红细胞压积值。贫血定义为血细胞比容小于40%。结果纳入了2764

据发表于JAMA Pediatric的一项新的研究显示,新生儿心脏手术前贫血与其术后死亡率的增加相关。

术前贫血是导致成人术后死亡的一个强有力的独立危险因素,但是在新生儿中是否也由此关系则尚未可知。

研究采用回顾性分析设计,使用来自美国外科学会国家外科质量改进计划的2012年和2013年的儿童数据库的数据。记录所有新生儿(0-30天)术前红细胞压积值。贫血定义为血细胞比容小于40%。

结果纳入了2764名新生儿,男性占64.5%,白种人占66.3%,妊娠期大于36周的占69.9%,体重超过2公斤的占85%。术后新生儿住院期间的死亡率为3.4%,其他年龄段(0-18岁)死亡率为0.6%。术前红细胞压积水哦小于40%为预测住院期间死亡的最佳节点(Youden)。

多变量回归分析显示,术前贫血是新生儿死亡发生的独立危险因素(OR, 2.62; 95% CI, 1.51-4.57)。术前红细胞压积水平低于40%的新生儿其术后住院期间的死亡率显著升高,为7.5% (95% CI, 1%-10%) VS.术前红细胞压积水平≥40%的新生儿为1.4% (95% CI, 0%-4%)。

该研究首次确定了新生儿术前贫血,术后住院期间死亡,以及术前贫血与术后死亡之间相关。及时诊断,预防以及适当的治疗术前贫血或可提高新生儿的存活率。

原始出处:

Goobie SM, et al. Association of Preoperative Anemia With Postoperative Mortality in Neonates. JAMA Pediatr. 2016;doi:10.1001/jamapediatrics.2016.1032.

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    2017-01-07 爆笑小医
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    2016-11-04 ylzr123

    新生儿术前贫血,术后住院期间死亡及术前贫血与术后死亡之间相关。及时诊断,预防及适当的治疗术前贫血或可提高新生儿的存活率。

    0

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    2016-10-31 xyfg98

    谢谢分享!

    0

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    2016-10-28 刘煜

    知晓了谢谢分享。

    0

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