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Heart:儿童期房间隔缺损手术闭合后极远期转归较佳

2013-07-30 高晓方 译 cmt

荷兰一项研究表明,儿童期房间隔缺损(ASD)手术闭合的极远期转归较佳,伴有良好生存率和较低发病率。论文于7月25日在线发表于《心脏》(Heart)。 此项纵向队列研究共纳入135例于年龄<15岁时接受ASD手术修补的序贯性患者。患者接受心电图、心脏超声、运动试验、N端脑利钠肽前体测定、Holter监测和心脏MRI扫描等检查。主要转归指标为生存率、心室功能以及心脏再介入、卒中、症状性心律失常

荷兰一项研究表明,儿童期房间隔缺损(ASD)手术闭合的极远期转归较佳,伴有良好生存率和较低发病率。论文于7月25日在线发表于《心脏》(Heart)。

此项纵向队列研究共纳入135例于年龄<15岁时接受ASD手术修补的序贯性患者。患者接受心电图、心脏超声、运动试验、N端脑利钠肽前体测定、Holter监测和心脏MRI扫描等检查。主要转归指标为生存率、心室功能以及心脏再介入、卒中、症状性心律失常或心衰等严重事件。

结果显示,35年后获取了131例患者(97%)的生存状况,其中5例(4%)死亡。14例(16%)患者伴有症状性室上性快速型心律失常,6例(6%)置入起搏器;上述情况可由术后早期心律失常所预测。2例患者接受再次手术。1例患者出现缺血性卒中。左室和右室射血分数(EF)分别为58±7%和51±6%。17例(31%)患者出现右室EF降低,11例(20%)伴有右室扩张。患者的运动能力和生活质量与正常人群相当。ASD-II和静脉窦型ASD之间无显著差异。

Cuypers JA, Opic P, Menting ME, Utens EM, Witsenburg M, Helbing WA, van den Bosch AE, Ouhlous M, van Domburg RT, Meijboom FJ, Bogers AJ, Roos-Hesselink JW.The unnatural history of an atrial septal defect (ASD): longitudinal follow-up of 35 years after surgical ASD closure at young age.Heart. 2013 Jul 25. [Epub ahead of print]

PMID:
23886606

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    2013-08-01 zhaojie88
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    2013-08-01 slcumt

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