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AJG:非酒精性脂肪性肝病和肌肉减少症与心血管风险独立相关

2020-03-21 MedSci原创 MedSci原创

目前已知,非酒精性脂肪肝疾病(NAFLD)和肌肉减少症与动脉粥样硬化性心血管疾病(ASCVD)的风险增加密切相关。因此,本项研究旨在验证NAFLD和少肌症对ASCVD风险的影响。

目标:目前已知,非酒精性脂肪肝疾病(NAFLD)和肌肉减少症与动脉粥样硬化性心血管疾病(ASCVD)的风险增加密切相关。因此,本项研究旨在验证NAFLD和少肌症对ASCVD风险的影响。

方法: 研究人员分析了2008-2011年韩国全国健康和营养检查调查数据库中的数据纳入了合格的患者(n = 7,191)。使用双能X射线吸收法计算肌肉减少症指数。肌肉减少症定义为最低的五分之一肌肉减少症指数值(男性的临界值= 0.882,女性的临界值= 0.582)。NAFLD被定义为≥40的综合NAFLD分数。使用fibrosis-4(FIB-4)指数评估肝纤维化。使用美国心脏病学会/美国心脏协会指南评估了ASCVD风险。ASCVD的高可能性定义为ASCVD风险> 10%。

结果: NAFLD和肌肉减少症的患病率分别为31.2%(n = 2,241)和19.5%(n = 1,400)。四分位数分层的ASCVD风险评分与NAFLD和肌肉减少症呈正相关(P<0.001)。与没有NAFLD和肌肉减少症的对照组相比,同时患有NAFLD和肌肉减少症的受试者发生ASCVD的可能性更高(OR= 1.83,P = 0.014)。在患有NAFLD的受试者中,与没有FIB-4的对照组相比,FIB-4定义为明显的肝纤维化或肌肉减少症,与没有FIB-4的对照组相比,肌肉减少症增加了ASCVD的高风险(优势比= 3.56,P <0.001)。

讨论: 在一般人群中,NAFLD和肌肉减少症与ASCVD风险增加显着相关。此外,NAFLD伴有明显的肝纤维化和肌肉减少症与NACVD的ASCVD风险增加显着相关。

原始出处:

Han, Eugene. Et al. Nonalcoholic Fatty Liver Disease and Sarcopenia Are Independently Associated With Cardiovascular Risk. The American Journal of Gastroenterology.2020.

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    2020-11-06 minzju5052
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channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Thu Jul 23 18:06:58 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673571, encodeId=53a816e3571db, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Sat Oct 24 03:06:58 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381378, encodeId=0e713813e87b, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Mon Apr 06 06:40:41 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393395, encodeId=d2b313933959e, content=<a href='/topic/show?id=e2f4809e7e9' target=_blank style='color:#2F92EE;'>#肌肉减少症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80977, encryptionId=e2f4809e7e9, topicName=肌肉减少症)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIOca9icPByKxo3ZRUrvuibf7tWt7EScQ1NEiaKy4NCUctSU2jDjOayLicDIaicwUxaQhJ1SZKdEevgjRg/132, createdBy=4f272500131, createdName=若水123, createdTime=Mon Mar 23 05:06:58 CST 2020, time=2020-03-23, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1654044, encodeId=b884165404436, content=<a href='/topic/show?id=1e1584351b2' target=_blank style='color:#2F92EE;'>#脂肪性肝病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84351, encryptionId=1e1584351b2, topicName=脂肪性肝病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46224431741, createdName=wwzzly, createdTime=Thu Apr 30 23:06:58 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676554, encodeId=698816e655499, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=, 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channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Thu Jul 23 18:06:58 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673571, encodeId=53a816e3571db, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Sat Oct 24 03:06:58 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381378, encodeId=0e713813e87b, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Mon Apr 06 06:40:41 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393395, encodeId=d2b313933959e, content=<a href='/topic/show?id=e2f4809e7e9' target=_blank style='color:#2F92EE;'>#肌肉减少症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80977, encryptionId=e2f4809e7e9, topicName=肌肉减少症)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIOca9icPByKxo3ZRUrvuibf7tWt7EScQ1NEiaKy4NCUctSU2jDjOayLicDIaicwUxaQhJ1SZKdEevgjRg/132, createdBy=4f272500131, createdName=若水123, createdTime=Mon Mar 23 05:06:58 CST 2020, time=2020-03-23, status=1, ipAttribution=)]
    2020-11-30 qjddjq
  6. 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createdName=若水123, createdTime=Mon Mar 23 05:06:58 CST 2020, time=2020-03-23, status=1, ipAttribution=)]
  7. 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  8. 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    2020-04-06 thm112988

    0

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