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皮肤细胞培育血细胞 大写的赞!

2017-05-26 佚名 环球医学编写

根据世界卫生组织(WHO)的数据,全世界每年收到超过1.07亿捐赠的血液,它们大部分被用于拯救生命。但捐赠血液的地区分配是不平衡的,许多迫切需要血液的地方(如发展中国家)没有足够的血液,而发达国家常常是供大于求。5月25日,《自然》杂志发表的一项由美国科学家进行的研究,科学家首次使用人类多能干细胞培育制造人类血液细胞。献血时代或将终结?

根据世界卫生组织(WHO)的数据,全世界每年收到超过1.07亿捐赠的血液,它们大部分被用于拯救生命。但捐赠血液的地区分配是不平衡的,许多迫切需要血液的地方(如发展中国家)没有足够的血液,而发达国家常常是供大于求。5月25日,《自然》杂志发表的一项由美国科学家进行的研究,科学家首次使用人类多能干细胞培育制造人类血液细胞。献血时代或将终结?

为了产生功能性人类造血干细胞,研究人员让人类多能干细胞经过成形素定向分化成为生血内皮,之后筛查26个造血干细胞指定转录因子在小鼠宿主中,促进多系造血的移植的能力。研究人员发现7个移植因子(ERG、HOXA5、HOXA9、HOXA10、LCOR、RUNX1和SPI1)足够将生血内皮转换成造血干细胞和祖细胞,原代和二代小鼠受体中移植髓细胞、B细胞和T细胞。

研究人员使用小鼠作为活体细胞工厂,制造的血液干细胞可以生成4种类型的血液细胞。这意味着能够为患者完美订制匹配的血液类型,尤其是那些失去造血功能的白血病或者化疗患者。

波士顿儿童医院资深科学家乔治?戴利(George Daley)博士说:“令人欣慰的是,我们即将能在器皿中培育出良性人类造血干细胞。”本研究有望研制血液疾病的个性化治疗,同时可以缓解短缺的捐献血液。

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    2017-05-27 杨利洪

    关注其临床推广

    0

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    2017-05-27 1ddf2f5fm10(暂无匿称)

    皮肤细胞这几个字在文章什么地方出现了?下面一群人在那赞,真是醉了

    0

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    2017-05-26 184****9840

    学习了谢谢分享。

    0

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    2017-05-26 Y—xianghai

    学习了,很好。

    0

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    2017-05-26 三生有幸9135

    学习一下谢谢分享

    0

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