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Am J Kidney Dis:血液透析患者心胸比和全因死亡率与心血管事件有啥关系?

2017-02-14 xing.T MedSci原创

较高的心胸比与血液透析患者全因死亡率和心血管事件风险增加相关。

通过X线胸片得到的心胸比通常用于评估容量状态。然而,很少研究报道血液透析患者心胸比和临床结局发生率之间的相关性。近日,肾脏病领域权威杂志Am J Kidney Dis上针对这一临床问题发表了一篇研究文章。

该研究采用前瞻性队列研究设计,研究人员纳入了日本18岁以上接受维持性血液透析的3436名Q-队列研究的参与者。该研究的主要结局指标为全因死亡率和心血管疾病(CVD)事件。

在4年的随访期间,564例(16.4%)患者死于任何原因,而590例(17.2%)患者发生了CVD事件。根据基础心胸比,由于心胸比的性别分布不同,参与者被分为性别特异的四分位。较高的心胸比的患者4年无事件生存率、全因死亡率和心血管事件显著降低。相比于最低心胸比参与者(第1四分位数),第2、3和4四分位数参与者经多变量调整后的全因死亡率风险比分别为0.89(95%可信区间为0.66-1.20)、1.41(1.08-1.86)和1.52(1.17-2.00)。同样,相比于第1四分位数参与者,第2、3和4四分位数参与者经多变量调整后的CVD事件风险比分别为1.0(95%可信区间为0.77-1.31)、1.18(0.92-1.53)和1.37(1.07-1.76)。此外,将较高的心胸比和正常低血压相组合(收缩压<140 mmHg和舒张压<90 mmHg)与CVD事件风险增高有关。

由此可见,较高的心胸比与血液透析患者全因死亡率和心血管事件风险增加相关。

原始出处:


Ryusuke Yotsueda,et al. Cardiothoracic Ratio and All-Cause Mortality and Cardiovascular Disease Events in Hemodialysis Patients: The Q-Cohort Study. Am J Kidney Dis.2017. http://dx.doi.org/10.1053/j.ajkd.2016.11.026

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    2017-02-16 habb
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    2017-02-16 gwc389

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