Brit J Cancer：晚期非小细胞肺癌患者疾病负荷与血浆游离DNA水平

2017-07-10 zhangfan MedSci原创

对于晚期非小细胞肺癌患者，突变的循环游离DNA水平与患者肿瘤代谢负担显著相关。血浆突变DNA阳性患者其生存期显著降低，血浆突变DNA是患者生存期预测的重要预测因子

目前普遍认为存在突变循环游离DNA（cfDNA）是肿瘤负荷及侵袭性疾病的主要指标。近日研究人员利用F18-D-葡萄糖正电子发射计算机断层显像/计算机断层扫描(18F-FDG PET/CT)研究了血浆突变cfDNA水平与肿瘤代谢负担(MTB)之间的关系并进一步考察突变的cfDNA与患者生存率之间的关系。研究招募了56名晚期非小细胞肺癌患者(NSCLC)。在研究基线时对患者进行血样采集通过新一代测序技术(NGS)获得cfDNA信息同时进行PET / CT扫描已获得患者MTB。研究对41名患者进行NGS测序，其中24名患者检测出血液突变。肿瘤代谢负担与最频繁突变的等位基因频率存在显著相关性(P=0.001)。血液cfDNA突变阳性的患者相比于阴性患者其中位生存期显著缩短 (3.7 vs 10.6个月， P=0.019)且cfDNA是独立的肿瘤代谢负担影响因子。研究表明，对于晚期非小细胞肺癌患者，突变的循环游离DNA水平与患者肿瘤代谢负担显著相关。血浆突变DNA阳性患者其生存期显著降低，血浆突变DNA是患者生存期预测的重要预测因子。原始出处：Anne Winther-Larsen et al.

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2018-05-04 wgx306

#DNA水平#

61 0
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2017-07-25 gds2009

#肺癌患者#

57 0
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2018-04-13 lingaifan

#非小细胞#

61 0
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2017-07-12 LSJ116

#游离DNA#

85 0
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2017-07-12 zxxiang

#非小细胞肺癌患者#

53 0
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2017-07-11 dpbl_zlh

PET-CT与ctDNA的二代测序，科研而已，在实际工作中的成本太高了吧。

83 0
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2017-07-11 ylzr123

感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！

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