Obstet Gynecol：产科难辨梭状芽孢杆菌感染的危险因素和发病率！

2018-01-28 xing.T MedSci原创

由此可见，妊娠艰难梭菌感染的诊断在过去15年中有所增加，这一诊断与产妇发病率和死亡率显著相关。

近日，妇产科权威杂志Obstetrics and Gynecology上发表了一研究文章，研究人员旨在评估产科难辨梭状芽孢杆菌感染的危险因素和发病率。

研究人员对来自美国的医疗费用和利用项目全国住院病人进行了一项回顾性队列研究，并对1999年至2013年间的孕妇分娩入院记录进行了审查。在对人口学指标和临床特征进行调整后，研究人员采用非条件logistic回归分析评估难辨梭状芽孢杆菌感染的危险因素。

在研究队列中，共分娩13881592例婴儿，研究人员发现2757例（0.02%）因分娩并发难辨梭状芽孢杆菌感染而入院。在研究期间，住院分娩的妇女难辨梭状芽孢杆菌感染率从15（95%CI为11.87-16.96）增加到30（24.42-31.78）/100000次分娩/每年（P＜0.001）。与艰难梭菌感染诊断相关的危险因素包括年龄超过35岁、多胎妊娠、吸烟、Crohn氏病、溃疡性结肠炎、长期使用抗生素、肺炎、肾盂肾炎以及剖宫产或会阴伤口感染。在妊娠时诊断为艰难梭菌感染与孕产妇死亡显著增加相关（8.0/1000 vs. 0.1/1000，调整后的比值比[OR]为56.8，95%CI为35.8-90.1）。此外，在艰难梭菌感染的孕妇中脓毒症（46.4/1000 vs. 0.6/1000，比值比为59.1，95%CI为48.8-71.6）、麻痹性肠梗阻（58.0/1000 vs. 1.5/1000，比值比为33.1，95%CI为27.5-39.8）、静脉血栓栓塞（38.4/1000 vs. 3.1/1000，比值比为8.1，95%CI为6.5-10.2）以及住院超过2周（173.0/1000 vs. 6.5/1000，比值比为24.3，95%CI为21.6-27.4）有所增加。

由此可见，妊娠艰难梭菌感染的诊断在过去15年中有所增加，这一诊断与产妇发病率和死亡率显著相关。

原始出处：

Ruiter-Ligeti, et al. Risk Factors, Incidence, and Morbidity Associated With Obstetric Clostridium difficile Infection.Obstetrics & Gynecology.2018. https://journals.lww.com/greenjournal/Abstract/publishahead/Risk_Factors,_Incidence,_and_Morbidity_Associated.98171.aspx

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#插入话题

插入图片

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2018-08-27 1249842em09(暂无昵称)

#NEC#

64 0
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2018-12-26 lifestar

#发病率#

75 0
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2018-10-05 daviiliu

#难辨梭状芽孢杆菌感染#

99 0
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2018-12-17 yhy100200

#TET#

62 0
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2018-09-17 chengjn

#芽孢杆菌#

72 0
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2018-01-28 zibozhouping

这哈u真的要注意.必要时检测一下.避免很多事件.谢谢

0 0
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2018-01-28 yfjms

学习

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