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Aliment Pharmacol Ther:益生菌还能预防院内感染!

2016-08-18 Seven L 译 MedSci原创

来自意大利的随机对照试验表明,益生菌乳酸菌GG、维生素B和C、以及锌混合物,可以预防儿童院内感染。来自费德里科二世大学的Alfredo Guarino博士和同事随机分配90例年龄6个月至5岁的儿童(平均年龄为25个月;50名为男孩)接受上述提到的混合物,或安慰剂;从住院第一天开始,持续15天。患者出院后7天和3个月随访患者,评估胃肠道和呼吸道医院感染的发生率。总体而言,20%的儿童发生院内感染;治

来自意大利的随机对照试验表明,益生菌乳酸菌GG、维生素B和C、以及锌混合物,可以预防儿童院内感染。

来自费德里科二世大学的Alfredo Guarino博士和同事随机分配90例年龄6个月至5岁的儿童(平均年龄为25个月;50名为男孩)接受上述提到的混合物,或安慰剂;从住院第一天开始,持续15天。患者出院后7天和3个月随访患者,评估胃肠道和呼吸道医院感染的发生率。

总体而言,20%的儿童发生院内感染;治疗组和对照组分别为9%和33%(P = .016);此外,治疗组和对照组分别有4%和24%的患者出现腹泻(P = .007)。

研究者称,出院后数月时间里,混合物仍对儿童的院内感染有保护作用。

治疗组和对照组的住院天数平均为3.9天和4.9天(P = .003)。3个月随访时,至少一次感染发作的比例在治疗组和对照组分别为24.4%和48.9%(P = .016)。

研究者说:研究结果支持并扩展了益生菌(乳酸杆菌GG)在急性感染方面的预防和治疗作用;混合物中的锌和维生素C可能会增强保护作用,虽然研究并没有直接探究这一方面,比较锌对营养不良儿童的感染是有效的,并且住院本身就是营养不良的风险因素。不过事实究竟是如何,还需要进一步的研究。

原始出处:

Probiotic, micronutrient mixture prevents nosocomial infection in children.Healio.August 17, 2016

Bruzzese E, et al.Randomised clinical trial: a Lactobacillus GG and micronutrient-containing mixture is effective in reducing nosocomial infections in children, vs. placebo. Aliment Pharmacol Ther. 2016;doi:10.1111/apt.13740.

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    2017-03-12 智智灵药
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createdTime=Sun Aug 21 16:24:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435202, encodeId=615e14352024e, content=<a href='/topic/show?id=1ccd983024d' target=_blank style='color:#2F92EE;'>#院内感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98302, encryptionId=1ccd983024d, topicName=院内感染)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Aug 20 12:37:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-09-21 jj000001
  4. 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createdTime=Sun Aug 21 16:24:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435202, encodeId=615e14352024e, content=<a href='/topic/show?id=1ccd983024d' target=_blank style='color:#2F92EE;'>#院内感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98302, encryptionId=1ccd983024d, topicName=院内感染)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Aug 20 12:37:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-09-07 ylzr123

    好文章,赞!深入学习。

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 07 17:35:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=105371, encodeId=52841053e15f, content=赞!文章有深度,值得收藏拜读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 08:31:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788182, encodeId=346a1e8818210, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, 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createdTime=Sun Aug 21 16:24:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435202, encodeId=615e14352024e, content=<a href='/topic/show?id=1ccd983024d' target=_blank style='color:#2F92EE;'>#院内感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98302, encryptionId=1ccd983024d, topicName=院内感染)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Aug 20 12:37:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-08-27 ylzr123

    赞!文章有深度,值得收藏拜读。

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 07 17:35:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=105371, encodeId=52841053e15f, content=赞!文章有深度,值得收藏拜读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 08:31:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788182, encodeId=346a1e8818210, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Mar 10 05:37:00 CST 2017, time=2017-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104418, encodeId=df62104418f3, content=这篇资讯写的真好,带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Aug 26 11:31:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), 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createdTime=Sun Aug 21 16:24:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435202, encodeId=615e14352024e, content=<a href='/topic/show?id=1ccd983024d' target=_blank style='color:#2F92EE;'>#院内感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98302, encryptionId=1ccd983024d, topicName=院内感染)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Aug 20 12:37:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 07 17:35:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=105371, encodeId=52841053e15f, content=赞!文章有深度,值得收藏拜读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Aug 27 08:31:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788182, encodeId=346a1e8818210, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, 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createdTime=Sun Aug 21 16:24:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435202, encodeId=615e14352024e, content=<a href='/topic/show?id=1ccd983024d' target=_blank style='color:#2F92EE;'>#院内感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98302, encryptionId=1ccd983024d, topicName=院内感染)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Aug 20 12:37:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-08-26 李东泽

    这篇资讯写的真好,带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。

    0

  8. 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createdTime=Sun Aug 21 16:24:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435202, encodeId=615e14352024e, content=<a href='/topic/show?id=1ccd983024d' target=_blank style='color:#2F92EE;'>#院内感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98302, encryptionId=1ccd983024d, topicName=院内感染)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Aug 20 12:37:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-08-26 李东泽

    这篇资讯写的真好,带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。

    0

  9. 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createdTime=Sun Aug 21 16:24:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435202, encodeId=615e14352024e, content=<a href='/topic/show?id=1ccd983024d' target=_blank style='color:#2F92EE;'>#院内感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98302, encryptionId=1ccd983024d, topicName=院内感染)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Aug 20 12:37:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-08-21 1e0d99ddm02(暂无匿称)

    这个可以有!!!

    0

  10. 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