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DRCP:Roux-en-Y胃旁路术可改善肥胖患者心血管功能

2013-09-03 MedSci MedSci原创

为了评估伴有2型糖尿病(T2DM)和高血压的肥胖患者腹腔镜Roux–en–Y胃旁路术(RYGB)疗效,并与用和不用艾塞那肽治疗的常规护理的相比较,来自第三军医大学西南医院内分泌科梁自文教授及其团队进行了一项研究,发现RYGB手术可改善伴有T2DM的肥胖高血压患者包括心血管功能在内的若干参数。该研究结果发表在2013年7月的Diabetes Research and Clinical Practic

为了评估伴有2型糖尿病(T2DM)和高血压的肥胖患者腹腔镜Roux–en–Y胃旁路术(RYGB)疗效,并与用和不用艾塞那肽治疗的常规护理的相比较,来自第三军医大学西南医院内分泌科梁自文教授及其团队进行了一项研究,发现RYGB手术可改善伴有T2DM的肥胖高血压患者包括心血管功能在内的若干参数。该研究结果发表在2013年7月的Diabetes Research and Clinical Practice 上,该杂志影响因子为2.741。

研究纳入了108例伴有高血压的肥胖T2DM患者,并随机分配到常规护理(组A),常规护理联合艾塞那肽治疗(组B)和RYGB手术(组C)。测量人口学特征、代谢参数和心脏结构/功能、以及炎症因子,并对12个月前后进行比较。

结果表明,12个月组A和组B没有患者发生糖尿病缓解,组C的90%患者出现糖尿病缓解,并且组C与组A和组B相比,降压药物的需求显著下降(P<0.05)。组B和组C患者的其他参数(体重指数、糖化血红蛋白、稳态模型评估的胰岛素抵抗、血脂),炎症指标(超敏C反应蛋白、肿瘤坏死因子–α、高分子量脂联素)和心脏结构(左心室质量指数)显著改善,但组C患者有最大程度的改善(P<0.05)。

研究发现,RYGB手术改善伴有T2DM的肥胖高血压患者若干参数,包括心血管功能。这可能是由于,至少部分是由于异常代谢功能改善和炎症的减少。

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