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PLoS One:儿童死于急性下呼吸道感染(ALRI)的危险因素研究

2015-02-03 MedSci MedSci原创

为了评估在低收入和中等收入国家的儿童死于急性下呼吸道感染(ALRI) 的危险因素 ,我们进行了一项系统回顾与Meta分析。 我们基于Medline, Embase, Global Health Library, Lilacs, and Web of Science数据库检索了截止到2014年1月以前的来自低收入和中等收入国家5岁以下死于急性下呼吸道感染(ALRI) 的危险因素相关的观察性研究文章

为了评估在低收入和中等收入国家的儿童死于急性下呼吸道感染(ALRI) 的危险因素 ,我们进行了一项系统回顾与Meta分析。

我们基于Medline, Embase, Global Health Library, Lilacs, and Web of Science数据库检索了截止到2014年1月以前的来自低收入和中等收入国家5岁以下死于急性下呼吸道感染(ALRI) 的危险因素相关的观察性研究文章。对预后研究工具稍作调整来评估风险因素的偏差,发表偏倚采用漏斗图和埃格检验评估。

在被检索的10655项研究报告中,来自39个国家(198359 儿童)的77项研究满足入选标准。

与ALRI死亡率更直接相关的宿主与疾病特征有:按照WHO定义确诊为及其严重的肺炎(odds ratio 9.42, 95% CI 6.37-13.92) ;年龄低于2个月(5.22, 1.70-16.03);诊断为卡氏肺孢子虫(4.79, 2.67-8.61) ;慢性基础疾病(4.76, 3.27-6.93);HIV/AIDS (4.68, 3.72-5.90);严重营养不良(OR 4.27, 3.47-5.25)。

与ALRI死亡率更直接相关的社会经济和环境因素有:年轻母亲的年龄(1.84, 1.03?3.31);母亲受教育程度低(1.43, 1.13?1.82);低社会经济地位(1.62, 1.32?2.00);二手烟暴露(1.52, 1.20 to 1.93); 室内空气污染(3.02,3.02 - 2.11)。免疫接种(0.46,0.36 - -0.58)和良好的产前检查(0.50,0.50 - 0.31) 与死亡率的降低相关。

基于以上研究结果得出宿主疾病,社会经济和成长环境因素影响着儿童死于急性下呼吸道感染((ALRI的风险)。慢性病的防治,干预措施来防治(如贫困,缺乏女性教育和恶劣的环境条件)等来降低在低收入和中等收入国家的儿童死于急性下呼吸道感染(ALRI) 的死亡率是人们亟待考虑和进行的的拯救措施。

原始出处

Sonego M1, Pellegrin MC2, Becker G3, Lazzerini M3.Risk Factors for Mortality from Acute Lower Respiratory Infections (ALRI) in Children under Five Years of Age in Low and Middle-Income Countries: A Systematic Review and Meta-Analysis of Observational Studies.PLoS One. 2015 Jan 30;

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1789640, encodeId=87051e8964076, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Wed Dec 16 04:55:00 CST 2015, time=2015-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17073, encodeId=a71f1e073c9, content=学习一下如何进行亚组分析, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3cff1613085, createdName=kalemia, createdTime=Fri Feb 27 09:24:00 CST 2015, time=2015-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282369, encodeId=993c128236990, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Thu Feb 05 07:55:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486525, encodeId=3a0014865254a, content=<a href='/topic/show?id=43e320132fa' target=_blank style='color:#2F92EE;'>#下呼吸道感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20132, encryptionId=43e320132fa, topicName=下呼吸道感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4608143316, createdName=循证小兵, createdTime=Thu Feb 05 07:55:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15020, encodeId=5fc815020d9, content=要更细地亚组分析, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Tue Feb 03 18:32:00 CST 2015, time=2015-02-03, status=1, ipAttribution=)]
    2015-02-27 kalemia

    学习一下如何进行亚组分析

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1789640, encodeId=87051e8964076, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Wed Dec 16 04:55:00 CST 2015, time=2015-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17073, encodeId=a71f1e073c9, content=学习一下如何进行亚组分析, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3cff1613085, createdName=kalemia, createdTime=Fri Feb 27 09:24:00 CST 2015, time=2015-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282369, encodeId=993c128236990, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Thu Feb 05 07:55:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486525, encodeId=3a0014865254a, content=<a href='/topic/show?id=43e320132fa' target=_blank style='color:#2F92EE;'>#下呼吸道感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20132, encryptionId=43e320132fa, topicName=下呼吸道感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4608143316, createdName=循证小兵, createdTime=Thu Feb 05 07:55:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15020, encodeId=5fc815020d9, content=要更细地亚组分析, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Tue Feb 03 18:32:00 CST 2015, time=2015-02-03, status=1, ipAttribution=)]
    2015-02-05 zhmscau
  4. [GetPortalCommentsPageByObjectIdResponse(id=1789640, encodeId=87051e8964076, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Wed Dec 16 04:55:00 CST 2015, time=2015-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17073, encodeId=a71f1e073c9, content=学习一下如何进行亚组分析, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3cff1613085, createdName=kalemia, createdTime=Fri Feb 27 09:24:00 CST 2015, time=2015-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282369, encodeId=993c128236990, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Thu Feb 05 07:55:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486525, encodeId=3a0014865254a, content=<a href='/topic/show?id=43e320132fa' target=_blank style='color:#2F92EE;'>#下呼吸道感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20132, encryptionId=43e320132fa, topicName=下呼吸道感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4608143316, createdName=循证小兵, createdTime=Thu Feb 05 07:55:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15020, encodeId=5fc815020d9, content=要更细地亚组分析, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Tue Feb 03 18:32:00 CST 2015, time=2015-02-03, status=1, ipAttribution=)]
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    2015-02-03 223.104.5.**

    要更细地亚组分析

    0

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