NRR：黄岑苷能促进慢性应激大鼠海马区的神经发生?

一项关于“Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats”的研究，通过连续14 d皮下注射40 mg/kg糖皮质激素建立成年SD大鼠慢性应激模型，与此同时灌胃50 mg/kg的黄岑苷，观察其对慢性应激大鼠神经发生的影响。

结果显示皮下注射糖皮质激素可显著降低海马中doublecortin阳性神经元数目，且糖皮质激素导致的海马神经元减少以II型doublecortin阳性神经元为主，而I型doublecortin阳性神经元不受影响。

 免疫组织化学染色可见黄岑苷干预后慢性应激模型大鼠海马齿状回doublecortin阳性表达

黄岑苷可显著提高糖皮质激素诱导的慢性应激模型大鼠海马中I型和II型doublecortin阳性神经元数目。此外，黄岑苷还能逆转糖皮质激素注射可引起doublecortin阳性神经元树突形态发生萎缩。

作者认为，黄岑苷具有促进成体动物海马神经发生的作用，可能使其在改善认知功能和情绪调节中有潜在的治疗作用和临床应用前景。

该结果发表在《中国神经再生研究（英文版）》(Neural Regeneration Research)杂志2013年2月第6期。与黄岑苷相关的拓展阅读：

• NRR：黄岑苷能促进慢性应激大鼠海马区的神经发生?

DOI: 10.3969/j.issn.1673-5374.2013.06.002

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Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats

Xinghua Jiang, Junmei Xu, Dingquan Zou, Lin Yang, Yaping Wang.

Chronic stress models, established in adult Sprague-Dawley rats through a 14-day subcutaneous injection of 40 mg/kg corticosterone, once per day, were given a daily oral feeding of 50 mg/kg baicalin. The study was an attempt to observe the effect of baicalin on neurogenesis in chronically stressed rats. Results showed that subcutaneous injection of corticosterone significantly decreased the total number of doublecortin-positive neurons in the hippocampus. The reduced cell number caused by corticosterone was mainly due to the decrease of class II doublecortin-positive neurons, but the class I doublecortin-positive neurons were unaffected. Baicalin treatment increased the number of both class I and class II doublecortin-positive neurons. In addition, doublecortin-positive neurons showed less complexity in dendritic morphology after corticosterone injection, and this change was totally reversed by baicalin treatment. These findings suggest that baicalin exhibits a beneficial effect on adult neurogenesis.