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Arthritis Care Res:美国患有风湿性关节炎老兵病因死亡的调查结果

2015-06-27 范伟译 MedSci原创

背景:在风湿性关节炎的男性中对病因特异性死亡和相关的风险因素之间进行了有限的调查。我们调查患有风湿性关节炎男性所有死因以及病因特异性死亡,检查其存活的决定因素。方法:男性是从纵向风湿性关节炎RA注册中心招募进来直到死亡或整个2013年间的。使用全国死亡指数确定重要的状态和死因。计算所有死因,心血管疾病(CVD),癌症和呼吸道死亡的粗死亡率和标准化死亡率(SMRs)。采用多变量Cox比例风险和竞争-

背景:在风湿性关节炎的男性中对病因特异性死亡和相关的风险因素之间进行了有限的调查。我们调查患有风湿性关节炎男性所有死因以及病因特异性死亡,检查其存活的决定因素。

方法:男性是从纵向风湿性关节炎RA注册中心招募进来直到死亡或整个2013年间的。使用全国死亡指数确定重要的状态和死因。计算所有死因,心血管疾病(CVD),癌症和呼吸道死亡的粗死亡率和标准化死亡率(SMRs)。采用多变量Cox比例风险和竞争-风险回归方程,对所有死因及病因特异性死亡进行检查。

结果:风湿性关节炎RA的男性有1652人,332人死亡。心血管疾病CVD(31.6%;标准化死亡率1.77,95%置信区间1.46 -2.14),癌症(22.9%;标准化死亡率1.50;95%置信区间1.20 -1.89)和呼吸道疾病(15.1%;标准化死亡率2.90;95%置信区间2.20 -3.83)是死亡的主要原因。与死亡率相关的因素包括年龄、高加索种族、吸烟、较低的体重、并发症、疾病活动指数和强的松的使用。类风湿因子浓度与心血管疾病死亡率有关,而结节与心血管疾病和呼吸道相关死亡有关。甲氨蝶呤或生物药剂的使用与各种死因或病因特异性死亡无关联。

结论:在风湿性关节炎RA组里,男性所有死因以及病因特异性死亡有增加,在一般群体中呼吸相关的死亡风险相比同龄男性要高3倍。还需要进一步的研究来检验是否针对潜在的“可修改的”相关死亡率的干预措施可能导致风湿性关节炎的男性有改善的长期生存期。

原始出处:

England BR1, Sayles H1, Michaud K1,2, Caplan L3, Davis LA3,4, Cannon GW5, Sauer BC5, Solow EB6, Reimold AM6, Kerr GS7, Schwab P8, Baker JF9, Mikuls TR1.Cause-Specific Mortality in US Veteran Men with Rheumatoid Arthritis.Arthritis Care Res (Hoboken). 2015 Jun 19. doi: 10.1002/acr.22642. 

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    2015-06-29 lmm397
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    2015-06-29 zhaojie88
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新近一项研究显示,诊断时对风湿性关节炎(RA)患者进行12项生物标志物血液检测,可分辨出1年内影像学进展风险极低的患者。这一多项生物标志物疾病活动度测试(multiple-biomarker disease activity test,MBDA;加利福尼亚南旧金山 Crescendo Bioscience Inc.)已在美国上市,用于检测RA的疾病活动度。斯德哥尔摩卡罗林斯卡研究院的Dr. Kar

STM:风湿性关节炎新型治疗方法

一项新的研究发现一类新的治疗风湿性关节炎的潜在治疗靶点,该靶点能够显著提高风湿性关节炎的治疗效果,同时不会引起免疫反应。这项研究是由美国加利福尼亚州La Jolla过敏与免疫研究所,细胞生物学分所的Karen M. Doody博士领导完成的,该研究发表在今年5月20号的 science Translational Medcine 杂志上。 "目前这方面的治疗方法通常是通过破坏免疫系统达到治疗的目的

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纽约新近一项研究指出,风湿性关节炎的治疗烟雾可大幅增加患者2年后关节损伤和发生残疾的可能性。相关研究结果将在10月28日圣地亚哥美国风湿病学会/美国风湿病卫生专业人员协会上发表。 “我们需要对风湿性关节炎的患者进行相关教育。一些患者因为害怕而延误治疗。他们并未把这一疾病记在心上,或不愿意开始药物治疗。一些患者仅采用非药物方法,但多数非药物疗法作用有限,”研究的主导者Bykerk博士说。 “不幸

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