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JAHA:院外心脏骤停幸存者早期心脏磁共振查出心肌水肿的预后作用

2021-11-16 MedSci原创 MedSci原创

早期心脏磁共振成像的ME表明急性和短暂的致心律失常基质,预测SCA幸存者的长期心律失常结局良好。这些结果可能会对未来SCA幸存者治疗指南产生重大的影响。

心脏骤停(SCA)可能由急性和可逆的心肌损伤、慢性和不可逆的心肌损伤或原发性室性心律失常所引起。心脏磁共振成像可以识别心肌水肿(ME),它提示急性和可逆性的心肌损伤。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员在随访期间评估了SCA幸存者的心律失常结局,并进一步评估了ME的预后作用。

研究人员连续纳入了来自9个合作中心的101名(71%为男性,中位年龄为47岁)SCA幸存者,他们接受了早期(<1个月)心脏磁共振成像检查并接受了植入式心脏复律除颤器(ICD)。在T2加权序列中,101名患者中有18名(18%)患者发现了ME。根据心脏磁共振成像检查结果,心律失常性SCA归因于急性心肌损伤(缺血性[n=10]或炎症性[n=8])、慢性结构性心脏病(缺血性心脏病[n=11]、心肌病)[n=20],或其他[n=23])或主要为心律失常综合征(n=29)。

在47个月(28至67个月)的随访期间,101名患者中有24名(24%)患者接受了适当的ICD干预治疗。ME与无任何ICD干预(log-rank=0.04)和ICD电击(log-rank=0.03)的显著更高的生存率相关,并且在调整左心室射血分数和晚期钆增强后仍然是更好的心律失常结局的独立预测因子。适当的ICD干预的风险与潜在心脏病的类型无关。

由此可见,早期心脏磁共振成像的ME表明急性和短暂的致心律失常基质,预测SCA幸存者的长期心律失常结局良好。这些结果可能会对未来SCA幸存者治疗指南产生重大的影响。

原始出处:

Alessandro Zorzi,et al.Prognostic Role of Myocardial Edema as Evidenced by Early Cardiac Magnetic Resonance in Survivors of Out‐of‐Hospital Cardiac Arrest: A Multicenter Study.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.021861

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    2021-11-17 zhaohui6731
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    2021-11-17 小华子
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应力心脏磁共振成像(CMR)在单中心研究中显示了良好的诊断和预后价值。本研究的目的旨在通过多中心研究评估应力CMR的预后价值及其后续的花费。本研究纳入了来自美国13个医学中心因胸痛转诊接受应力CMR检查的患者,主要终点事件是心源性死亡或非致死性心梗。最终,共纳入了2349名患者(平均年龄为63±11岁,女性占47%),平均随访时间是5.4年。CMR显示有1583名(67%)患者无缺血或晚期钆增强(

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