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Lancet Gastroen Hepatol:1990-2017年间全球胃食管反流病负担研究

2020-03-16 MedSci原创 MedSci原创

胃食管反流病在全世界都很常见,但东亚地区的发病率较低。近日30年来,全球年龄标准化胃食管反流病流行率保持稳定

胃食管反流病是一种常见的慢性病,导致食管腺癌风险增加。近日研究人员利用2017年全球疾病、伤害和危险因素研究(GBD)的数据,对1990-2017年间195个国家和地区的胃食管反流病负担进行了考察。

本次研究为系统性回顾分析,研究采用DisMod-MR贝叶斯混合效应元回归工具以确定1990-2017年间全球范围内地理分布人群胃食管反流病的患病率。使用胃食管反流病患者症状频率和严重程度的来估计在给定时间内无症状、轻中度症状或严重至非常严重症状患病率,并对健康寿命损失年(YLD)进行评估。

总体而言,胃食管反流疾病负担研究数据较少,共有144个地理位置-年的患病率数据,包含39个(20%)国家及地区数据。2017年所有地区年龄标准化患病率的平均估计值从每100000人口4408例到每100000人口14035例不等。年龄标准化患病率在美国、意大利、希腊、新西兰以及拉丁美洲和加勒比、北非和中东以及东欧等国家最高(大于每10万人口11000例);在高收入亚太地区、东亚、冰岛、法国、丹麦和瑞士最低(小于每10万人口7000例)。全球患病率在75-79岁达到高峰,为每10万人口18820例。1990-2017年间,全球年龄标准化流行率稳定(1990年每10万人口8791例;2017年每10万人口8819例,变化率为0.3%),但1990年至2017年间,全年龄标准化患病率增加了18.1%,从1990年每10万人口7859例增加到2017年的每10万人口9283例。1990-2017年,YLDs增加了67.1%,从1990年的360万增加到2017年的601万。

胃食管反流病在全世界都很常见,但东亚地区的发病率较低。近日30年来,全球年龄标准化胃食管反流病流行率保持稳定。

原始出处:

GBD 2017 Gastro-oesophageal Reflux Disease Collaborators. The global, regional, and national burden of gastro-oesophageal reflux disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroen Hepatol, March 13, 2020.

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    2020-09-01 许安
  4. 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  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Mar 18 09:47:08 CST 2020, time=2020-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571682, encodeId=8a9415e1682fc, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Wed Mar 18 09:47:08 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
    2020-08-25 howi
  6. [GetPortalCommentsPageByObjectIdResponse(id=2046137, encodeId=cf4f204613e24, content=<a href='/topic/show?id=010b3e767b2' target=_blank style='color:#2F92EE;'>#反流病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37767, encryptionId=010b3e767b2, topicName=反流病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Wed Oct 14 18:47:08 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712351, encodeId=b1561e12351a4, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, 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content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Wed Mar 18 09:47:08 CST 2020, time=2020-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437522, encodeId=6319143e5221d, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Mar 18 09:47:08 CST 2020, time=2020-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571682, encodeId=8a9415e1682fc, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Wed Mar 18 09:47:08 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
    2020-03-18 天地飞扬

    学习

    0

  7. 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  8. 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    2020-03-18 gwc384
  9. 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    2020-03-18 zhouqu_8
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    2020-03-18 feifers

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