Heart：海产衍生n-3脂肪酸或降心源性死亡风险

　　日本一项研究表明，海产衍生n-3脂肪酸（MDn3FA）或可降低与J点抬高相关的心源性死亡风险。论文5月10日在线发表于《心脏》（Heart）。

　　在日本和格陵兰，鱼是饮食的主要成分。既往研究发现，人饮食摄取海产n—3脂肪酸、鱼与冠心病发病率低相关。

　　此项基于人群的前瞻性队列研究共纳入4348例社区男性。受试者平均年龄49.3岁，并且基线时均无心血管疾病。利用家庭称重食物记录评估膳食MDn3FA摄入。主要转归指标为24年随访期间的心源性死亡。

　　结果显示，340例（7.8%）受试者存在J点抬高。中位每日MDn3FA摄入为0.35%kcal（0.92 g/天）。在MDn3FA低摄入组中，J点抬高者的心源性死亡风险显著高于无J点抬高者[校正危险比（HR ）3.51，P<0.001]；但在高摄入组中则非如此。MDn3FA摄入和J点抬高对心源性死亡风险的交互影响具有统计学意义（P=0.006）

　　注：J波是体表心电图（ECG）上紧邻QRS波群后一个呈拱顶或驼峰形状的波。J波综合征可为遗传性，如早期复极（ER）模式和Brugada综合征（BrS），也可为获得性。

Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: a 24-year follow-up of Japanese men.
OBJECTIVE
Higher marine-derived n-3 fatty acids (MDn3FAs) intake reduces the risk of sudden cardiac death via antiarrhythmic effects. The article evaluates whether MDn3FAs intake attenuates the increased risk of cardiac death associated with J-point elevation (JPE), characterised by an elevation of QRS-ST junction (J-point) ≥0.1 mV on electrocardiography.
DESIGN
A prospective population-based cohort study.
SETTING
The National Survey on Circulatory Disorders and the National Nutrition Survey of Japan.
PARTICIPANTS
A total of 4348 community-dwelling men (mean age 49.3 years), without cardiovascular diseases at baseline, from randomly selected areas across Japan.
MAIN OUTCOME MEASURES
Cardiac death (200 men) during the 24-year follow-up.
RESULTS
Dietary MDn3FAs intake was assessed using a dietary method to estimate individual intake of household-based weighed food records for 3 days. Cox models were used to calculate HRs and 95% CIs adjusted for possible confounding factors. JPE was present in 340 participants (7.8%). The median daily intake of MDn3FAs was 0.35%kcal (0.92 g/day). The risk of cardiac death was significantly higher in participants with JPE than in those without JPE in the low intake group (<0.35%kcal; adjusted HR 3.51; 95% CI 1.84 to 6.73; p<0.001), but not in the high intake group (≥0.35%kcal; adjusted HR 1.09; 95% CI 0.56 to 2.16; p=0.795). The interaction between dietary MDn3FAs intake and JPE on the risk of cardiac death was statistically significant (p=0.006).
CONCLUSIONS
The increased risk of cardiac death associated with JPE may be attenuated by higher dietary MDn3FAs intake.