SCI REP：食管鳞状细胞癌患者手术获益

2017-04-08 MedSci MedSci原创

食管癌是常见的肿瘤之一，预后差死亡率高。手术对于可切除的食管癌是重要的治疗手段，尤其是对于食管腺癌。食管切除术后高并发症发生率以及高复发率使得人们逐渐关注食管癌的综合治疗，如同时放化疗合并或不合并手术治疗。对于食管癌最适宜的治疗方式仍存在争议。

食管癌是常见的肿瘤之一，预后差死亡率高。手术对于可切除的食管癌是重要的治疗手段，尤其是对于食管腺癌。食管切除术后高并发症发生率以及高复发率使得人们逐渐关注食管癌的综合治疗，如同时放化疗合并或不合并手术治疗。对于食管癌最适宜的治疗方式仍存在争议。

SCI REP近期报道了一篇文章，研究了手术治疗是否可以改善食管鳞状细胞癌患者的预后情况。作者回顾性分析了2007年到2014年间诊断的T2-T4期食管鳞状细胞癌患者1230例，超过70%的患者年龄在65岁以下，超过85%的患者诊断时分期在T3-T4.中位生存时间是1.06年。生存分析表明生存时间与年龄、T分期、淋巴结受累情况以及治疗方式（手术或放化疗）有关。多因素分析表明手术对于患者总生存存在有力的影响。接受根治性手术的患者死亡风险明显低于仅接受放化疗的患者。进一步分析表明，对于T3N+以及T4患者，手术联合新辅助治疗与单纯手术治疗或放化疗相比对于患者生存情况的改善更为明显。

文章最后认为，接受手术治疗的患者生存期更长。因此对于适合接受手术治疗的食管癌患者，手术应作为考虑的治疗手段。对于可切除的T3-T4食管鳞状细胞癌，应手术联合新辅助治疗。

原始出处：

Miao-Fen Chen,Ping-Tsung Chen,et al.Survival benefit of surgery to patients with esophageal squamous cell carcinoma.SCI REP.06 April 2017 doi:10.1038/srep46139

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2017-09-01 qingting

#细胞癌#

70 0
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2017-04-11 1771ae4158m

学习一下很不错

113 0
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2017-04-11 1771ae4158m

学习一下很不错

112 0
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2017-04-11 1771ae4158m

学习一下很不错

121 0
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2017-04-10 venlin

#食管鳞状细胞癌#

70 0
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2017-04-10 zhouqu_8

#食管#

86 0
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2017-04-09 半夏微凉

学习了谢谢！

0 0
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level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sun Apr 09 06:34:13 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186101, encodeId=5a1f1861015e, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Apr 09 06:23:36 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186072, encodeId=1a711860e264, content=感谢分享一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, 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2017-04-09 1e1c07bdm01(暂无匿称)

好

119 0
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2017-04-09 刘煜

学习了谢谢分享。

73 0
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2017-04-09 laymankey

感谢分享一下！

68 0

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