Baidu
map

治疗神经性疼痛:普瑞巴林是良药

2016-09-25 佚名 Medicalxpress

根据在线发表于9月9日的《疼痛实践》上的研究结果,不管之前有没有用过加巴喷丁,普瑞巴林对于神经性疼痛的治疗都是有益的。 来自纽约罗彻斯特大学医学院的John D. Markman博士和同事们收集了来自在神经性疼痛患者身上进行的18项有关普瑞巴林的随机、双盲试验。作者们比较了普瑞巴林介导的疼痛改变和疼痛相关的睡眠干预得分、最终患者整体印象变化分数以及不良反应在那些之前接受和未接受加巴喷丁的

根据在线发表于9月9日的《疼痛实践》上的研究结果,不管之前有没有用过加巴喷丁,普瑞巴林对于神经性疼痛的治疗都是有益的。

 

来自纽约罗彻斯特大学医学院的John D. Markman博士和同事们收集了来自在神经性疼痛患者身上进行的18项有关普瑞巴林的随机、双盲试验。作者们比较了普瑞巴林介导的疼痛改变和疼痛相关的睡眠干预得分、最终患者整体印象变化分数以及不良反应在那些之前接受和未接受加巴喷丁的患者身上的发生情况。

 

研究人员发现,不管在任何时间点使用多大剂量的普瑞巴林,在之前接受和未接受过加巴喷丁的患者群体之间,疼痛缓解以及疼痛相关睡眠干扰的缓解程度并没有差别。并且,在研究结束时,患者整体印象变化分数或者不良反应的发生情况分布在接受和未接受加巴喷丁治疗的患者群中也没有显著性差异。

 

“这些研究发现支持了一个观点,即普瑞巴林也许能成功用于那些患有神经性疼痛同时对加巴喷丁反应较差或不能耐受的患者。”作者们写道。“这些结果强调了根据个体对不同治疗(包括同种机制下的多种试剂的应用)的反应来调整神经性疼痛治疗的重要性。”

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2035404, encodeId=1064203540469, content=<a href='/topic/show?id=d382e42956d' target=_blank style='color:#2F92EE;'>#神经性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74295, encryptionId=d382e42956d, topicName=神经性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d310, createdName=hywen7326, createdTime=Mon Mar 13 21:00:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138950, encodeId=c2021389507c, content=很好,有帮助,很喜欢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160930/IMG57EDFF4739EBF3035.jpg, createdBy=0da11618734, createdName=右脚梅西, createdTime=Sun Oct 02 11:49:39 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310296, encodeId=9a561310296bb, content=<a href='/topic/show?id=24795994515' target=_blank style='color:#2F92EE;'>#普瑞巴林#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59945, encryptionId=24795994515, topicName=普瑞巴林)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Tue Sep 27 14:00:00 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372908, encodeId=39b513e2908be, content=<a href='/topic/show?id=b38ee4304bf' target=_blank style='color:#2F92EE;'>#神经性疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74304, encryptionId=b38ee4304bf, topicName=神经性疼痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76fa353, createdName=tm10051981, createdTime=Tue Sep 27 14:00:00 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2035404, encodeId=1064203540469, content=<a href='/topic/show?id=d382e42956d' target=_blank style='color:#2F92EE;'>#神经性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74295, encryptionId=d382e42956d, topicName=神经性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d310, createdName=hywen7326, createdTime=Mon Mar 13 21:00:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138950, encodeId=c2021389507c, content=很好,有帮助,很喜欢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160930/IMG57EDFF4739EBF3035.jpg, createdBy=0da11618734, createdName=右脚梅西, createdTime=Sun Oct 02 11:49:39 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310296, encodeId=9a561310296bb, content=<a href='/topic/show?id=24795994515' target=_blank style='color:#2F92EE;'>#普瑞巴林#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59945, encryptionId=24795994515, topicName=普瑞巴林)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Tue Sep 27 14:00:00 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372908, encodeId=39b513e2908be, content=<a href='/topic/show?id=b38ee4304bf' target=_blank style='color:#2F92EE;'>#神经性疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74304, encryptionId=b38ee4304bf, topicName=神经性疼痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76fa353, createdName=tm10051981, createdTime=Tue Sep 27 14:00:00 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
    2016-10-02 右脚梅西

    很好,有帮助,很喜欢。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2035404, encodeId=1064203540469, content=<a href='/topic/show?id=d382e42956d' target=_blank style='color:#2F92EE;'>#神经性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74295, encryptionId=d382e42956d, topicName=神经性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d310, createdName=hywen7326, createdTime=Mon Mar 13 21:00:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138950, encodeId=c2021389507c, content=很好,有帮助,很喜欢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160930/IMG57EDFF4739EBF3035.jpg, createdBy=0da11618734, createdName=右脚梅西, createdTime=Sun Oct 02 11:49:39 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310296, encodeId=9a561310296bb, content=<a href='/topic/show?id=24795994515' target=_blank style='color:#2F92EE;'>#普瑞巴林#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59945, encryptionId=24795994515, topicName=普瑞巴林)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Tue Sep 27 14:00:00 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372908, encodeId=39b513e2908be, content=<a href='/topic/show?id=b38ee4304bf' target=_blank style='color:#2F92EE;'>#神经性疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74304, encryptionId=b38ee4304bf, topicName=神经性疼痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76fa353, createdName=tm10051981, createdTime=Tue Sep 27 14:00:00 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2035404, encodeId=1064203540469, content=<a href='/topic/show?id=d382e42956d' target=_blank style='color:#2F92EE;'>#神经性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74295, encryptionId=d382e42956d, topicName=神经性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d310, createdName=hywen7326, createdTime=Mon Mar 13 21:00:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138950, encodeId=c2021389507c, content=很好,有帮助,很喜欢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160930/IMG57EDFF4739EBF3035.jpg, createdBy=0da11618734, createdName=右脚梅西, createdTime=Sun Oct 02 11:49:39 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310296, encodeId=9a561310296bb, content=<a href='/topic/show?id=24795994515' target=_blank style='color:#2F92EE;'>#普瑞巴林#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59945, encryptionId=24795994515, topicName=普瑞巴林)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Tue Sep 27 14:00:00 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372908, encodeId=39b513e2908be, content=<a href='/topic/show?id=b38ee4304bf' target=_blank style='color:#2F92EE;'>#神经性疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74304, encryptionId=b38ee4304bf, topicName=神经性疼痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76fa353, createdName=tm10051981, createdTime=Tue Sep 27 14:00:00 CST 2016, time=2016-09-27, status=1, ipAttribution=)]

相关资讯

A&R:AS患者的背痛是一种包含有神经性疼痛在内的混合性疼痛

AS患者足背机械阈值和寒冷敏感性较健康对照组相比下降 AS患者的初级体觉皮质区、岛叶皮层、前扣带皮层、前中扣带皮层及辅助运动区的脑皮质变薄,而脑灰质的体积在丘脑及豆状核壳中增加 AS患者的疼痛检测积分与初级体觉皮质区脑灰质的减少相关,与运动皮质区、前扣带皮层、前额皮质、丘脑及纹状体中脑灰质的增加相关 强直性脊柱炎(AS)的病变主要累及中轴脊柱,是引起下腰背痛症状的常见疾病。为

Neuron:胚胎干细胞用于治疗神经性疼痛

近日,加州大学旧金山分校的科学家们发现使用胚胎干细胞能用来治疗神经性疼痛。 加州大学旧金山分校的科学家完成的一项新研究证实:细胞疗法可能有一天被用来治疗一些常见类型的疼痛症状。 研究人员在小鼠身上开展的研究,关注于治疗神经损伤引起的慢性疼痛即所谓的神经性疼痛。 相关研究论文发表在Neuron杂志上,在他们的研究中,科学家们在老鼠大脑中移植不成熟的胚胎神经细胞,在大脑中神经细胞被用来更新特定的

Neurology:普瑞巴林可有效治疗脊髓损伤所致神经性疼痛

  美国学者的一项研究表明,普瑞巴林可有效治疗脊髓损伤所致神经性疼痛,并且耐受性良好。论文于2013年1月23日在线发表于《神经病学》(Neurology)。   此项研究共纳入220例脊髓损伤所致慢性神经性疼痛患者,并随机给予为期17周的普瑞巴林(108例)或安慰剂(112例)治疗。依据损伤神经平面相关性对疼痛加以分类。主要转归指标为持续时间校正的疼痛平均改变。关键性次要转归指标包括基线至终点

降低2型糖尿病患者神经性疼痛的新型药物

在Molecular Medicine杂志上发表的一项新研究报告中,研究人员在显著减轻2型糖尿病患者临床疼痛方面获得重大突破。 这项研究由Araim Pharmaceuticals完成,并开发出慢性疾病的创新治疗方法,研究人员还观察到服用ARA290患者的代谢控制得到改善。ARA290是一种肽,被研究人员进行改造以激活机体内的先天修复受体,该受体由Araim科学家发现,只在组织损伤或应激情况下表

Baidu
map
Baidu
map
Baidu
map