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JCEM：长期持续性轻度亚临床甲减可能会增加儿童心血管风险

2014-06-12 MedSci MedSci原创

甲减亚临床心血管
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亚临床甲减的心血管风险已得到公认。然而在儿童与青少年中尚不清楚。最新一项研究表明，作者选择了轻度亚临床甲减儿童和青少年（血清TSH浓度在4.5-10 mU/L）水平，但未经任何治疗进行长期随访观察，平均随访3.2±0.4 年。总共选择49例8.5±0.5岁的轻度亚临床甲减儿童，以及49例正常对照儿童。观察收缩压，舒张压，BMI，腰围身高比（WHtR ），脂质水平，同型半胱氨酸水

亚临床甲减的心血管风险已得到公认。然而在儿童与青少年中尚不清楚。最新一项研究表明，作者选择了轻度亚临床甲减儿童和青少年（血清TSH浓度在4.5-10 mU/L）水平，但未经任何治疗进行长期随访观察，平均随访3.2±0.4 年。总共选择49例8.5±0.5岁的轻度亚临床甲减儿童，以及49例正常对照儿童。观察收缩压，舒张压，BMI，腰围身高比（WHtR ），脂质水平，同型半胱氨酸水平，血清高敏CRP， fibrinogen, adiponectin, insulin 和HOMA index。结果发现，与正常对照组相比，WHtR (p<0.0001), atherogenic index (p =0.001), triglycerides/HDL-Cholesterol ratio (p= 0.01) 和 homocysteine levels (p=0.002) 都显著上升，而HDL-Cholesterol显著下降 (p=0.003) 。多元回归分析发现BMI是甲状腺状态的独立风险因素，即便校正BMI后，这些变量仍然与TSH水平或亚临床甲减相关。虽然，在儿童中无法征测出心血管风险，但这些指标提示这些儿童将来动脉粥样硬化的可能性更大。


原始出处：
Manuela C, Capalbo D, Wasniewska M, Mattace Raso G, Alfano S, Meli R, De Luca F, Salerno M.CARDIOVASCULAR RISK FACTORS IN CHILDREN WITH LONG-STANDING UNTREATED IDIOPATHIC SUBCLINICAL HYPOTHYROIDISM. J Clin Endocrinol Metab. 2014 May 19:jc20141761.

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    2014-10-24 achengzhao

    #JCE#

    0

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    2015-02-01 smallant2015

    #JCEM#

    0

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    2014-07-30 ms5353107019656438

    #血管风险#

    0

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    2014-11-25 liuyg0228

    #持续性#

    0

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    2014-06-14 12498cf9m35(暂无昵称)

    #甲减#

    0

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