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JAMA Intern Med:骨质疏松、共病、预后与髋部骨折风险

2019-06-24 MedSci MedSci原创

高龄骨质疏松症妇女,特别是那些患有较多并发症或预后较差的妇女,其髋部骨折风险较高

目前老年人使用药物进行预防性骨折治疗的比例较低,但共病大大增加了老年人群的骨质疏松症治疗的复杂性。近日研究人员就80岁及以上女性5年髋部骨折概率与共患疾病和预后的关系进行了考察。

1528名社区妇女参与研究,每4个月进行一次随访以确定患者状况和髋部骨折情况。计算了5年髋部骨折概率,。根据国家骨骼健康联盟提出的疾病定义,参与者被分为两个不同的组:骨质疏松症(n=761)和无骨质疏松症但骨折风险高(n=767)。

这项研究共有1528名参与者,均为女性,平均年龄为84.1岁)。随访期间,125例(8.0%)女性发生髋部骨折,287例(18.8%)在骨折事件前死亡。骨质疏松妇女5年死亡率为24.9%,无骨质疏松但风险高的妇女为19.4%。骨质疏松妇女5年髋部骨折概率为13.0%,无骨质疏松但风险高的女性5年髋部骨折概率为4.0%。这种差异最明显的是那些患有更多共同疾病或预后更差的妇女。例如,在3种或3种以上共病妇女中,骨质疏松妇女髋部骨折的概率为18.1%,而无骨质疏松但骨折风险较高的妇女为2.5%。

高龄骨质疏松症妇女,特别是那些患有较多并发症或预后较差的妇女,其髋部骨折风险较高。

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    2019-06-26 liuquan
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    2019-06-26 Eleven17
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    2019-06-24 qingfengqishi5

    学习了,学习了

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