JEM：揭示microRNA分子在炎性肠病发病过程中的关键角色

2017-05-10 生物谷生物谷

近日，一项刊登在国际杂志The Journal of Experimental Medicine上的一篇题为“Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome”的研究报告中，来自国外的研究人员

近日，一项刊登在国际杂志The Journal of Experimental Medicine上的一篇题为“Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome”的研究报告中，来自国外的研究人员通过研究发现，特定白细胞产生的microRNA分子能够抑制肠道组织的过度炎症表现，研究者指出，合成形式的microRNA分子能够降低小鼠机体肠道的炎症，本文研究或许就为后期研究人员开发治疗克罗恩病或溃疡性结肠炎的新型疗法提供了新的思路和希望。

图片摘自：Neudecker et al., 2017

炎性肠病（IBD）包括克罗恩病和溃疡性结肠炎，尽管一系列复杂的遗传和环境因子会诱发IBD发生，但研究人员认为IBD的发生是由机体肠道应对细菌感染所产生的过度免疫反应所引起，这种免疫反应包括不同白细胞的募集，比如中性粒细胞和单核细胞，这些细胞会被招募进入肠道，同时也会在名为炎性体的细胞中诱发蛋白复合体的激活，随后这些炎性体就会激活促炎性信号分子IL-1β和IL-18，进而刺激更多白细胞产生反应。

microRNA是一类小型的RNA分子，其能够结合并且抑制信使RNA的表达，研究人员通过研究发现，IBD患者在活动性炎症爆发期间往往机体中名为miR-223的microRNA分子水平较高，而且这种microRNA分子在患结肠炎的小鼠机体中水平也较高。中性粒细胞和单核细胞能够产生miR-223分子，此前研究者认为miR-223能够抑制信使RNA编码NLRP3组分的功能，NLRP3是炎性体的关键组分；研究者发现，缺失miR-223的小鼠机体中会表达高水平的NLRP3，从而诱发IL-1β的增加，并且增强机体对肠道炎症的易感性。

相比较而言，利用包含模拟miR-223分子的合成性RNA分子的脂质纳米颗粒对小鼠进行治疗就能够降低NLRP3和IL-1β的水平，同时还能够免于机体结肠炎的发生。最后研究者McNamee说道，本文研究发现，miR-223-NLRP3-IL-1β调节性通路或许是肠道炎症发生的关键组分，miR-223能够抑制NLRP3炎性体激活的水平，同时其还能够早期限制机体过度炎症的表现，而对miR-223分子进行遗传或药理学地稳定或许就能够为研究者后期开发治疗炎性肠病提供新的希望和靶点。

原始出处：

Viola Neudecker, Moritz Haneklaus, Owen Jensen, et al. Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. J. Exp. Med. May 9, 2017 DOI: 10.1084/jem.20160462

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2017-06-06 jiafufeng@yaho

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2018-02-07 xjy02

#Micro#

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2018-02-02 446798725_87912765

#RNA分子#

68 0
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2017-06-21 lofter

学习了，感谢分享

99 0
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2017-06-19 1e1263e3m20(暂无匿称)

长见识了，很不错

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2017-05-14 ylzr123

感谢小编为我们精心准备了如此精辟的精神大餐，小编辛苦了，点个赞吧！

132 0
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2017-05-13 卡圣

学习了，谢谢.

117 0
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2017-05-12 zhouqu_8

#microRNA#

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