Meta分析基本原理与分析过程介绍

2015-07-04 MedSci MedSci原创

无论是定性变量数据还是定量变量数据，Meta分析的基本步骤是相同的。若异质性过大，应放弃Meta分析，只对结果作统计描述。Meta分析本身并不能提高原始研究质量，并不能克服低质量原始研究的自身缺陷。系统评价遵循设计清晰、有据可循、方法学完善的原则，注意是否存在系统误差(偏倚)和随机误差(由机遇产生)，减少其对科研质量的影响，更加客观、更加全面地反映了原始研究文献的观点。一、循证医学与研究证

无论是定性变量数据还是定量变量数据，Meta分析的基本步骤是相同的。若异质性过大，应放弃Meta分析，只对结果作统计描述。Meta分析本身并不能提高原始研究质量，并不能克服低质量原始研究的自身缺陷。系统评价遵循设计清晰、有据可循、方法学完善的原则，注意是否存在系统误差(偏倚)和随机误差(由机遇产生)，减少其对科研质量的影响，更加客观、更加全面地反映了原始研究文献的观点。一、循证医学与研究证据循证医学是研究如何遵循临床研究证据指导医学实践的学科，提倡医务人员在临床实践中将个人专业技能和经验、病人的需求与当前最好的科学依据结合起来制定医疗决策。其实践过程包括创造证据、获取证据、应用证据和再评价证据、不断完善和更新证据。循证医学中证据主要是指人体试验的证据，包括病因、诊断、预防、治疗、康复和预后等方面的证据，并追求证据的质量和不断补充完善。证据的论证强度可根据其质量和可靠程度分为五级。一级证据：按照特定病种的特定疗法收集所有质量可靠的随机对照试验后所作的系统评价或Meta-分析。二级证据：样本量足够大的单个随机对照试验结果。三级：设有对照组但未用随机方法分组的研究。四级：无

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2021-06-07 朝雾

非常详尽，感谢分享

80 0
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2015-10-04 仁心济世

#MET#

54 0
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2016-01-01 guojianrong

#Meta#

52 0
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2015-08-06 hlycom3356

感谢作者的努力

130 0
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2015-08-06 hlycom3356

我从中学习了很多

126 0
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2015-08-06 hlycom3356

功能很强大

110 0
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2015-07-19 Chaddock

nv好

106 0
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2015-07-06 owlhealth

挺好的

161 0
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2015-07-05 18619c0a62m

(⊙o⊙)

94 0
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2015-07-05 18619c0a62m

呵呵

86 0

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