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JAHA:荟萃分析显示——摄入钾可降低卒中发生的风险

2016-11-01 MedSci MedSci原创

背景:许多观察性队列研究,包括一些最近的报告发现,生活方式的因素,如饮食,特别是钾的摄入量,可能改变卒中发生的风险。研究者对现有的研究进行了系统的回顾和荟萃分析,评估钾摄入量和卒中风险之间的剂量-反应关系。方法和结果:研究者回顾了2016年8月6日以前的观察队列研究,这些研究探讨钾的摄入量和总卒中或卒中亚型的发病率或死亡率的关系。研究者进行了基于比较最高与最低摄入量人群中卒中发生的相对风险(RR)

背景:许多观察性队列研究,包括一些最近的报告发现,生活方式的因素,如饮食,特别是钾的摄入量,可能改变卒中发生的风险。研究者对现有的研究进行了系统的回顾和荟萃分析,评估钾摄入量和卒中风险之间的剂量-反应关系。

方法和结果:研究者回顾了2016年8月6日以前的观察队列研究,这些研究探讨钾的摄入量和总卒中或卒中亚型的发病率或死亡率的关系。研究者比较了最高与最低摄入量人群中卒中发生的相对风险(RR),对16个队列研究进行荟萃分析。研究者根据钾的摄入还绘制了一个卒中发生RR混合的剂量反应曲线。校正血压或不校正血压,进行分析。

在校正血压分析中,与钾摄入量最低的人群相比,钾摄入的最高的人群与卒中风险降低13%相关(RR = 0.87,95% CI 0.80-0.94)。当不校正血压时,RR值呈下降趋势。对脑卒中亚型的分析得到了相似的结果。在样条分析中,钾摄入量90 mmol/日时,总RR值最低,校正血压分析时RR = 0.78(95% CI 0.70-0.86),未校正血压分析时,RR值为0.67(95% CI 0.57-0.78)。

结论:总的来说,这个剂量效应的荟萃分析证实钾的摄入与卒中风险之间呈负相关,钾日摄入量为90 mmol(≈3500mg/d)与卒中发生风险最低相关。

原始出处:

Vinceti M, Filippini T,et al. Meta-Analysis of Potassium Intake and the Risk of Stroke. J Am Heart Assoc. 2016 Oct 6


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    2017-05-15 venlin
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    2017-01-24 wmu姿

    要怎评价钾摄入量够没够呢

    0

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    2016-11-10 1dedfe95m66(暂无匿称)

    电活动是动力

    0

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    2016-11-03 zhaohui6731
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