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Gut:低聚半乳糖缓解铁元素对肠道微生物的不良影响

2017-08-05 海北 MedSci原创

含有铁的微量元素粉末能够帮助非洲婴儿减少贫血的发生。但是,人们发现,高剂量铁元素的摄入(12.5mg/day)对于婴儿体内的肠道微生物会有影响。其会减少双歧杆菌和乳酸菌的数量,增加肠道病原菌的数量,增加婴儿腹泻以及呼吸道感染的风险。

含有铁的微量元素粉末能够帮助非洲婴儿减少贫血的发生。但是,人们发现,高剂量铁元素的摄入(12.5mg/day)对于婴儿体内的肠道微生物会有影响。其会减少双歧杆菌和乳酸菌的数量,增加肠道病原菌的数量,增加婴儿腹泻以及呼吸道感染的风险。 新型的微量元素粉末配方包括了益生元低聚半乳糖和低剂量高生物利用度的铁(5mg /天)。来自苏黎世联邦理工大学的研究人员评估了该配方的安全性和有效性。 在一个为期4个月的双盲对照实验中,研究人员将6.5-9.5个月的肯尼亚婴儿进行了随机分组,每天给婴儿摄入(1)不含铁的微量元素粉末(对照组);(2)含有5mg铁元素的微量元素粉末(Fe组);(3)含有5mg铁元素以及7.5g低聚半乳糖的微量元素粉末(FeGOS组)。 结果显示,和对照组相比,摄入铁元素的Fe组和FeGOS组婴儿的贫血发生率减少了50%。但是,和对照组相比,Fe组婴儿体内的双歧杆菌和乳杆菌的丰度降低,梭菌丰度升高,病原体的毒素和有害基因丰度上升,血浆肠道脂肪酸结合蛋白升高(这是肠细胞损伤的生物标志物),呼吸道感染的发生率升高。相反,FeGOS组和对照组比较没有显著的差异,FeGOS组中病原体毒素

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    2023-03-02 灿漫 来自北京

    学习

    0

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  3. [GetPortalCommentsPageByObjectIdResponse(id=2117277, encodeId=3d30211e27752, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d34e5319148, createdName=灿漫, createdTime=Thu Mar 02 21:13:00 CST 2023, time=2023-03-02, status=1, ipAttribution=北京), GetPortalCommentsPageByObjectIdResponse(id=1824809, encodeId=ad80182480952, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Sep 28 08:42:00 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231890, encodeId=1b1e23189015, content=学习了,好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/01/a422505c84c5bd7df245dee314debefc.jpg, createdBy=31332101574, createdName=kalery, createdTime=Wed Aug 09 18:27:53 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588731, encodeId=61801588e3130, content=<a href='/topic/show?id=8ac523668e8' target=_blank style='color:#2F92EE;'>#乳糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23668, encryptionId=8ac523668e8, topicName=乳糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a5a17619424, createdName=minzju5058, createdTime=Mon Aug 07 00:42:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604643, encodeId=3751160464333, content=<a href='/topic/show?id=f3f696533f6' target=_blank style='color:#2F92EE;'>#铁元素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96533, encryptionId=f3f696533f6, topicName=铁元素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a19243899, createdName=chshh83, createdTime=Mon Aug 07 00:42:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230325, encodeId=927e230325a4, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Sat Aug 05 11:27:41 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230302, encodeId=42cd230302ff, content=筑底鞋驻地距, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIkNwCMvcaJiclcUnbibMY8aNMrNCO1ZwiaS6Na5waERicZaIP2UbGVwHvdnTVHwOetJuQoy1zFYyCGqw/0, createdBy=d8891630715, createdName=成恩, createdTime=Sat Aug 05 09:50:24 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-09 kalery

    学习了,好文章

    0

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    2017-08-07 minzju5058
  5. [GetPortalCommentsPageByObjectIdResponse(id=2117277, encodeId=3d30211e27752, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d34e5319148, createdName=灿漫, createdTime=Thu Mar 02 21:13:00 CST 2023, time=2023-03-02, status=1, ipAttribution=北京), GetPortalCommentsPageByObjectIdResponse(id=1824809, encodeId=ad80182480952, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Sep 28 08:42:00 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231890, encodeId=1b1e23189015, content=学习了,好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/01/a422505c84c5bd7df245dee314debefc.jpg, createdBy=31332101574, createdName=kalery, createdTime=Wed Aug 09 18:27:53 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588731, encodeId=61801588e3130, content=<a href='/topic/show?id=8ac523668e8' target=_blank style='color:#2F92EE;'>#乳糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23668, encryptionId=8ac523668e8, topicName=乳糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a5a17619424, createdName=minzju5058, createdTime=Mon Aug 07 00:42:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604643, encodeId=3751160464333, content=<a href='/topic/show?id=f3f696533f6' target=_blank style='color:#2F92EE;'>#铁元素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96533, encryptionId=f3f696533f6, topicName=铁元素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a19243899, createdName=chshh83, createdTime=Mon Aug 07 00:42:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230325, encodeId=927e230325a4, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Sat Aug 05 11:27:41 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230302, encodeId=42cd230302ff, content=筑底鞋驻地距, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIkNwCMvcaJiclcUnbibMY8aNMrNCO1ZwiaS6Na5waERicZaIP2UbGVwHvdnTVHwOetJuQoy1zFYyCGqw/0, createdBy=d8891630715, createdName=成恩, createdTime=Sat Aug 05 09:50:24 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-07 chshh83
  6. [GetPortalCommentsPageByObjectIdResponse(id=2117277, encodeId=3d30211e27752, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d34e5319148, createdName=灿漫, createdTime=Thu Mar 02 21:13:00 CST 2023, time=2023-03-02, status=1, ipAttribution=北京), GetPortalCommentsPageByObjectIdResponse(id=1824809, encodeId=ad80182480952, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Sep 28 08:42:00 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231890, encodeId=1b1e23189015, content=学习了,好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/01/a422505c84c5bd7df245dee314debefc.jpg, createdBy=31332101574, createdName=kalery, createdTime=Wed Aug 09 18:27:53 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588731, encodeId=61801588e3130, content=<a href='/topic/show?id=8ac523668e8' target=_blank style='color:#2F92EE;'>#乳糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23668, encryptionId=8ac523668e8, topicName=乳糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a5a17619424, createdName=minzju5058, createdTime=Mon Aug 07 00:42:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604643, encodeId=3751160464333, content=<a href='/topic/show?id=f3f696533f6' target=_blank style='color:#2F92EE;'>#铁元素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96533, encryptionId=f3f696533f6, topicName=铁元素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a19243899, createdName=chshh83, createdTime=Mon Aug 07 00:42:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230325, encodeId=927e230325a4, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Sat Aug 05 11:27:41 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230302, encodeId=42cd230302ff, content=筑底鞋驻地距, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIkNwCMvcaJiclcUnbibMY8aNMrNCO1ZwiaS6Na5waERicZaIP2UbGVwHvdnTVHwOetJuQoy1zFYyCGqw/0, createdBy=d8891630715, createdName=成恩, createdTime=Sat Aug 05 09:50:24 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 hhh678

    henhao

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2117277, encodeId=3d30211e27752, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d34e5319148, createdName=灿漫, createdTime=Thu Mar 02 21:13:00 CST 2023, time=2023-03-02, status=1, ipAttribution=北京), GetPortalCommentsPageByObjectIdResponse(id=1824809, encodeId=ad80182480952, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Sep 28 08:42:00 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231890, encodeId=1b1e23189015, content=学习了,好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/01/a422505c84c5bd7df245dee314debefc.jpg, createdBy=31332101574, createdName=kalery, createdTime=Wed Aug 09 18:27:53 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588731, encodeId=61801588e3130, content=<a href='/topic/show?id=8ac523668e8' target=_blank style='color:#2F92EE;'>#乳糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23668, encryptionId=8ac523668e8, topicName=乳糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a5a17619424, createdName=minzju5058, createdTime=Mon Aug 07 00:42:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604643, encodeId=3751160464333, content=<a href='/topic/show?id=f3f696533f6' target=_blank style='color:#2F92EE;'>#铁元素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96533, encryptionId=f3f696533f6, topicName=铁元素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a19243899, createdName=chshh83, createdTime=Mon Aug 07 00:42:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230325, encodeId=927e230325a4, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Sat Aug 05 11:27:41 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230302, encodeId=42cd230302ff, content=筑底鞋驻地距, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIkNwCMvcaJiclcUnbibMY8aNMrNCO1ZwiaS6Na5waERicZaIP2UbGVwHvdnTVHwOetJuQoy1zFYyCGqw/0, createdBy=d8891630715, createdName=成恩, createdTime=Sat Aug 05 09:50:24 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 成恩

    筑底鞋驻地距

    0

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