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BMJ:轻、中度饮酒确实增加癌症风险,但男女有差别

2015-09-11 崔倩 译 MedSci原创

研究人员进行此项研究的目的是分别量化女性和男性各个层面饮酒的总体癌症风险,重点放置于轻至中度饮酒和不吸烟者;并评估饮酒模式对总体癌症风险的影响。美国卫生专业人员进行了两项前瞻性队列研究。88084名女性和47881名男性参加了护士健康研究(1980年),卫生专业人员的随访研究从1986年开始,其后直至2010年。主要结果为癌症的相关风险。女性和男性参与者中分别有19269和7571(不包括非晚期前

研究人员进行此项研究的目的是分别量化女性和男性各个层面饮酒的总体癌症风险,重点在于轻至中度饮酒和不吸烟者;并评估饮酒模式对总体癌症风险的影响。美国卫生专业人员进行了两项前瞻性队列研究。

88084名女性和47881名男性参加了护士健康研究(1980年),卫生专业人员的随访研究从1986年开始,其后直至2010年。主要结果为癌症的相关风险。

女性和男性参与者中分别有19269和7571(不包括非晚期前列腺癌)例癌症事件,研究超过3144853人-年。与不饮酒者相比,女性轻、中度饮酒者酒精摄入量0.1-4.9和5-14.9 g/天总癌症相对风险分别为1.02(95%可信区间为0.98〜1.06)和1.04(1.00至1.09 Ptrend=0.12)。男性酒精摄入量0.1-4.9, 5-14.9,和15-29.9 g/天的相应值分别1.03(0.96〜1.11),1.05(0.97〜1.12),和1.06(0.98〜1.15;Ptrend=0.31)。轻度到中度饮酒与总癌症的联系在曾经吸烟和不吸烟的参与者中是相似的,虽然饮酒量高于中等水平(特别是≥30g/天)与总癌症风险的联系在曾经吸烟者中比不吸烟者更要强烈。对于在男性中预先定义的酒精与癌症相关,风险并没有在轻,中度饮酒并且不吸烟者中增加(Ptrend=0.18)。然而,对于女性,即使酒精摄入量5-14.9g/天增加了酒精相关的癌症风险(相对风险1.13(95%置信区间 1.06至1.20)),例如乳腺癌。在调整总酒精摄入量后,更加频繁和大量的饮酒不会进一步与总癌症风险相关。

轻、中度饮酒与癌症总风险略有增加有关。对于男性不吸烟者,轻度和中度饮酒(每天最多两杯)没有明显增加酒精有关的癌症风险。然而,对于从不吸烟的女性,甚至每天的饮酒量在含酒精饮料的范围内也会增加相关癌症的风险(主要是乳腺癌)。

原始出处:

Yin Cao,Walter C Willett,Eric B Rimm,et al.Light to moderate intake of alcohol, drinking patterns, and risk of cancer,BMJ,2015.8.18

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    2015-10-11 gaoxiaoe
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    2015-09-29 lyrichen

    酱紫

    0

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    2015-09-13 happy1

    为什么男女有差异?是不是乳腺癌对酒精有什么反应

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1847709, encodeId=28ee184e709c1, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Oct 11 21:33:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943479, encodeId=fae719434e91c, content=<a href='/topic/show?id=0f2122153ec' target=_blank style='color:#2F92EE;'>#中度饮酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22153, encryptionId=0f2122153ec, topicName=中度饮酒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Sun Apr 03 20:33:00 CST 2016, time=2016-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37555, encodeId=5bb83e55545, content=酱紫, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7311615220, createdName=lyrichen, createdTime=Tue Sep 29 17:34:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36865, encodeId=08f236865a8, content=为什么男女有差异?是不是乳腺癌对酒精有什么反应, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sun Sep 13 07:21:00 CST 2015, time=2015-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36824, encodeId=d25636824c5, content=有差别啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a521611487, createdName=ldqct1978, createdTime=Sat Sep 12 00:12:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36823, encodeId=7e653682368, content=评论为何失败, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCEEr4dM45RatXXGAkFCicnNYiasFiaRicicO1YWsIeTFOhgapauqib8Z8TChNB3ttVC5RqNHptDvAxA72Q/0, createdBy=a82a1611288, createdName=yydlt, createdTime=Sat Sep 12 00:10:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36820, encodeId=718f3682033, content=男女差异, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCEEr4dM45RatXXGAkFCicnNYiasFiaRicicO1YWsIeTFOhgapauqib8Z8TChNB3ttVC5RqNHptDvAxA72Q/0, createdBy=a82a1611288, createdName=yydlt, createdTime=Fri Sep 11 20:40:00 CST 2015, time=2015-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36818, encodeId=f6a2368189e, content=个体差异还是性别差异, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUNfdk68bHutYruGyxbKDzPWH3agcmId19Yf94FiapyicN0LTg0jykhqIhjPQVdR08FGR399rBpZIg/132, createdBy=feae1624323, createdName=Dr.LV, createdTime=Fri Sep 11 20:13:00 CST 2015, time=2015-09-11, status=1, ipAttribution=)]
    2015-09-12 ldqct1978

    有差别啊

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1847709, encodeId=28ee184e709c1, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Oct 11 21:33:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943479, encodeId=fae719434e91c, content=<a href='/topic/show?id=0f2122153ec' target=_blank style='color:#2F92EE;'>#中度饮酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22153, encryptionId=0f2122153ec, topicName=中度饮酒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Sun Apr 03 20:33:00 CST 2016, time=2016-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37555, encodeId=5bb83e55545, content=酱紫, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7311615220, createdName=lyrichen, createdTime=Tue Sep 29 17:34:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36865, encodeId=08f236865a8, content=为什么男女有差异?是不是乳腺癌对酒精有什么反应, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sun Sep 13 07:21:00 CST 2015, time=2015-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36824, encodeId=d25636824c5, content=有差别啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a521611487, createdName=ldqct1978, createdTime=Sat Sep 12 00:12:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36823, encodeId=7e653682368, content=评论为何失败, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCEEr4dM45RatXXGAkFCicnNYiasFiaRicicO1YWsIeTFOhgapauqib8Z8TChNB3ttVC5RqNHptDvAxA72Q/0, createdBy=a82a1611288, createdName=yydlt, createdTime=Sat Sep 12 00:10:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36820, encodeId=718f3682033, content=男女差异, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCEEr4dM45RatXXGAkFCicnNYiasFiaRicicO1YWsIeTFOhgapauqib8Z8TChNB3ttVC5RqNHptDvAxA72Q/0, createdBy=a82a1611288, createdName=yydlt, createdTime=Fri Sep 11 20:40:00 CST 2015, time=2015-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36818, encodeId=f6a2368189e, content=个体差异还是性别差异, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUNfdk68bHutYruGyxbKDzPWH3agcmId19Yf94FiapyicN0LTg0jykhqIhjPQVdR08FGR399rBpZIg/132, createdBy=feae1624323, createdName=Dr.LV, createdTime=Fri Sep 11 20:13:00 CST 2015, time=2015-09-11, status=1, ipAttribution=)]
    2015-09-12 yydlt

    评论为何失败

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1847709, encodeId=28ee184e709c1, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Oct 11 21:33:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943479, encodeId=fae719434e91c, content=<a href='/topic/show?id=0f2122153ec' target=_blank style='color:#2F92EE;'>#中度饮酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22153, encryptionId=0f2122153ec, topicName=中度饮酒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Sun Apr 03 20:33:00 CST 2016, time=2016-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37555, encodeId=5bb83e55545, content=酱紫, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7311615220, createdName=lyrichen, createdTime=Tue Sep 29 17:34:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36865, encodeId=08f236865a8, content=为什么男女有差异?是不是乳腺癌对酒精有什么反应, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sun Sep 13 07:21:00 CST 2015, time=2015-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36824, encodeId=d25636824c5, content=有差别啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a521611487, createdName=ldqct1978, createdTime=Sat Sep 12 00:12:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36823, encodeId=7e653682368, content=评论为何失败, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCEEr4dM45RatXXGAkFCicnNYiasFiaRicicO1YWsIeTFOhgapauqib8Z8TChNB3ttVC5RqNHptDvAxA72Q/0, createdBy=a82a1611288, createdName=yydlt, createdTime=Sat Sep 12 00:10:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36820, encodeId=718f3682033, content=男女差异, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCEEr4dM45RatXXGAkFCicnNYiasFiaRicicO1YWsIeTFOhgapauqib8Z8TChNB3ttVC5RqNHptDvAxA72Q/0, createdBy=a82a1611288, createdName=yydlt, createdTime=Fri Sep 11 20:40:00 CST 2015, time=2015-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36818, encodeId=f6a2368189e, content=个体差异还是性别差异, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUNfdk68bHutYruGyxbKDzPWH3agcmId19Yf94FiapyicN0LTg0jykhqIhjPQVdR08FGR399rBpZIg/132, createdBy=feae1624323, createdName=Dr.LV, createdTime=Fri Sep 11 20:13:00 CST 2015, time=2015-09-11, status=1, ipAttribution=)]
    2015-09-11 yydlt

    男女差异

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1847709, encodeId=28ee184e709c1, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Oct 11 21:33:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943479, encodeId=fae719434e91c, content=<a href='/topic/show?id=0f2122153ec' target=_blank style='color:#2F92EE;'>#中度饮酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22153, encryptionId=0f2122153ec, topicName=中度饮酒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Sun Apr 03 20:33:00 CST 2016, time=2016-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37555, encodeId=5bb83e55545, content=酱紫, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7311615220, createdName=lyrichen, createdTime=Tue Sep 29 17:34:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36865, encodeId=08f236865a8, content=为什么男女有差异?是不是乳腺癌对酒精有什么反应, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sun Sep 13 07:21:00 CST 2015, time=2015-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36824, encodeId=d25636824c5, content=有差别啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a521611487, createdName=ldqct1978, createdTime=Sat Sep 12 00:12:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36823, encodeId=7e653682368, content=评论为何失败, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCEEr4dM45RatXXGAkFCicnNYiasFiaRicicO1YWsIeTFOhgapauqib8Z8TChNB3ttVC5RqNHptDvAxA72Q/0, createdBy=a82a1611288, createdName=yydlt, createdTime=Sat Sep 12 00:10:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36820, encodeId=718f3682033, content=男女差异, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCEEr4dM45RatXXGAkFCicnNYiasFiaRicicO1YWsIeTFOhgapauqib8Z8TChNB3ttVC5RqNHptDvAxA72Q/0, createdBy=a82a1611288, createdName=yydlt, createdTime=Fri Sep 11 20:40:00 CST 2015, time=2015-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36818, encodeId=f6a2368189e, content=个体差异还是性别差异, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUNfdk68bHutYruGyxbKDzPWH3agcmId19Yf94FiapyicN0LTg0jykhqIhjPQVdR08FGR399rBpZIg/132, createdBy=feae1624323, createdName=Dr.LV, createdTime=Fri Sep 11 20:13:00 CST 2015, time=2015-09-11, status=1, ipAttribution=)]
    2015-09-11 Dr.LV

    个体差异还是性别差异

    0

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