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美亿万富翁斥巨资探寻癌症免疫新疗法

2016-04-21 徐徐 中国科学报

 Jeff Bluestone 图片来源:Cindy Chew 一名科技企业家能否提出开展癌症研究的更好方法?这是纳普斯特联合创始人、亿万富翁慈善家Sean Parker日前下的赌局。Parker将2.5亿美元注入一家研究癌症免疫疗法的新机构。相比之下,美国副总统拜登的“癌症登月”计划提议的经费是向国立卫生研究院(NIH)国家癌症研究所拨款6.8亿美元。不过,这一数目可能是

 Jeff Bluestone 图片来源:Cindy Chew

一名科技企业家能否提出开展癌症研究的更好方法?这是纳普斯特联合创始人、亿万富翁慈善家Sean Parker日前下的赌局。Parker将2.5亿美元注入一家研究癌症免疫疗法的新机构。相比之下,美国副总统拜登的“癌症登月”计划提议的经费是向国立卫生研究院(NIH)国家癌症研究所拨款6.8亿美元。不过,这一数目可能是年度资助水平,后续几年将持续进行。

Parker想在利用免疫系统对抗癌症的疗法上取得惊人的成功。多年来,使肿瘤在免疫系统面前原形毕露的被称为T细胞的基因工程免疫细胞和被称为“检查点抑制剂”的药物已能击败肿瘤,但这仅限于一些患有特定癌症类型的病人。

他的癌症免疫疗法帕克研究所将在6个癌症研究中心创建一个中心网络:加州大学旧金山分校(UCSF)、纽约纪念斯隆凯特琳癌症中心、宾夕法尼亚大学、哈佛大学、得克萨斯州安德森癌症中心。另一个“大玩家”——约翰斯·霍普金斯大学并未在名单上,但上个月获赠1.25亿美元用于癌症免疫疗法研究。

今年,每个帕克中心将收到1000万~1500万美元的资助,未来还将收到更多。UCSF免疫学家、帕克研究所首席执行官Jeffrey Bluestone表示,这些经费将用于基础研究、培训项目、人员招聘和临床试验。在一项不同寻常的安排中,这些中心已同意共享来自所有癌症免疫疗法研究的成果,即便是由其他来源资助的项目。反过来,研究人员将接触到尖端技术和经费以探索新想法,而无须提供资助申请书并为获得资助等上好几个月。

该研究所已选择3个初始的聚焦领域,正在寻找更高效制造基因工程T细胞的方法,并且正探寻为何仅有一些患者对检查点抑制剂作出反应。同时,它正在寻找肿瘤抗原——由肿瘤产生、能触发免疫反应的蛋白。这种抗原能被用于制造对抗癌症的疫苗和更好的细胞疗法。(徐徐)

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    2016-10-03 1e10c84am36(暂无匿称)

    深度好文,值得关注

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    2016-04-27 1dd8c52fm63(暂无匿称)

    好有钱啊!

    0

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    2016-04-23 kcb074
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    2016-04-21 李继凯

    文章高大上

    0

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    2016-04-21 李继凯

    值得关注

    0

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