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Eur J Cancer:非酒精性脂肪性肝病会增加胆道癌风险!

2021-04-27 Nebula MedSci原创

胆道癌(BTC),包括胆管癌和胆囊癌,是世界上第二常见的肝胆道癌症

胆道癌(BTC),包括胆管癌和胆囊癌,是世界上第二常见的肝胆道癌症。约70%的BTC患者在诊断时已是晚期。BTC患者往往对治疗高度耐药,5年生存率<20%。 既往病例对照研究显示,非酒精性脂肪性肝病(NAFLD)和胆管癌之间具有一定相关性。Park等人开展了一项全国范围的队列研究,以评估NAFLD与BTC风险的纵向相关性。 研究流程 根据韩国国民健康保险服务的数据,于2009年纳入了8120674名接受健康筛查的成年人。根据脂肪肝指数评估有无NAFLD:≥60,即NAFLD;30-59,即中等评分;<30,无NAFLD。排除标准为基线存在临床肝病、酗酒和癌症。随访至2017年12月,筛查有无罹患BTC。 根据脂肪肝指数分层的胆道癌风险 中位随访7.2年期间,共13043位患者新确诊为BTC。与无NAFLD相比,NAFLD与BTC的风险增加相关(校正风险比[aHR] 1.28,95%CI 1.20-1.37)。胆管癌和胆囊癌与NAFLD相关性的aHR分别是1.33(95%CI 1.23-1.43)和1.14(95%CI 1.003-1.29)。 NAFLD和BTC风险在不同亚

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    2021-09-26 qjddjq
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    2021-08-25 sjq027
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    2021-05-30 Crystal4509

    谢谢分享学习了

    0

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    2021-04-28 carrotlyl

    好消息

    0

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    2021-04-27 ms4000001619232656

    学习了

    0

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