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Neurology:注意力缺陷/多动障碍药物治疗可降低患者癫痫发作风险

2018-02-24 zhangfan MedSci原创

研究发现,接受注意力缺陷/多动障碍药物治疗可降低患者癫痫发作风险,该效果不受先前癫痫发作史的影响

统计发现患有注意力缺陷/多动障碍(ADHD)人群癫痫发作的风险增加,但目前尚不清楚ADHD药物治疗对癫痫风险的影响。

研究对801838名ADHD患者及其药物治疗情况进行考察,探讨ADHD药物治疗对癫痫的影响。首先,研究人员考察了ADHD患者中总的癫痫发病率,之后考察患者在接受药物治疗期间的癫痫发病率,最终考察癫痫发作与过去2年间药物治疗的相关性。

研究发现,ADHD患者其任何类型的癫痫风险显著提高(男性OR=2.33,女性OR=2.31)。内部比较调整后,对于之前有癫痫发作史的患者,ADHD药物治疗可减少患者癫痫复发风险(OR = 0.71, 95% CI = 0.60–0.85) ,而对于之前无癫痫发作史的患者,ADHD治疗同样有效(OR = 0.71, 95% CI = 0.62–0.82)。长期内部比较认为,无证据表明ADHD治疗可导致有(OR = 0.87, 95% CI = 0.59–1.30)或无 (OR = 1.01, 95% CI = 0.80–1.28)癫痫发作史患者癫痫复发风险增加。

研究发现,接受注意力缺陷/多动障碍药物治疗可降低患者癫痫发作风险,该效果不受先前癫痫发作史的影响。

原始出处:

Kelsey K. Wiggs et al. Attention-deficit/hyperactivity disorder medication and seizures.Neurology. February 23, 2018.

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    2018-11-18 yinhl1978
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    2018-02-24 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2018-02-24 龙胆草

    学习谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2000325, encodeId=068b200032525, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Nov 18 01:17:00 CST 2018, time=2018-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019113, encodeId=2e842019113bf, content=<a href='/topic/show?id=28c06501143' target=_blank style='color:#2F92EE;'>#注意力缺陷/多动障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65011, encryptionId=28c06501143, topicName=注意力缺陷/多动障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6732482, createdName=w984445tii, createdTime=Sat Jul 28 09:17:00 CST 2018, time=2018-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968840, encodeId=37d1196884021, content=<a href='/topic/show?id=01be430e1c3' target=_blank style='color:#2F92EE;'>#多动障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43071, encryptionId=01be430e1c3, topicName=多动障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Wed Jan 30 22:17:00 CST 2019, time=2019-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515696, encodeId=ea6c15156969a, content=<a href='/topic/show?id=cd636500e2e' target=_blank style='color:#2F92EE;'>#注意力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65007, encryptionId=cd636500e2e, topicName=注意力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=096e10855142, createdName=12498c24m72暂无昵称, createdTime=Sun Feb 25 22:17:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290470, encodeId=fb3f2904e048, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Feb 24 09:16:32 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290463, encodeId=124e29046388, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Feb 24 08:59:38 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290443, encodeId=d9bc29044354, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat Feb 24 08:29:01 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290422, encodeId=0a14290422b6, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Feb 24 07:44:04 CST 2018, time=2018-02-24, status=1, ipAttribution=)]
    2018-02-24 wzb521zf

    一起学习学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2000325, encodeId=068b200032525, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Nov 18 01:17:00 CST 2018, time=2018-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019113, encodeId=2e842019113bf, content=<a href='/topic/show?id=28c06501143' target=_blank style='color:#2F92EE;'>#注意力缺陷/多动障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65011, encryptionId=28c06501143, topicName=注意力缺陷/多动障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6732482, createdName=w984445tii, createdTime=Sat Jul 28 09:17:00 CST 2018, time=2018-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968840, encodeId=37d1196884021, content=<a href='/topic/show?id=01be430e1c3' target=_blank style='color:#2F92EE;'>#多动障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43071, encryptionId=01be430e1c3, topicName=多动障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Wed Jan 30 22:17:00 CST 2019, time=2019-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515696, encodeId=ea6c15156969a, content=<a href='/topic/show?id=cd636500e2e' target=_blank style='color:#2F92EE;'>#注意力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65007, encryptionId=cd636500e2e, topicName=注意力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=096e10855142, createdName=12498c24m72暂无昵称, createdTime=Sun Feb 25 22:17:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290470, encodeId=fb3f2904e048, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Feb 24 09:16:32 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290463, encodeId=124e29046388, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Feb 24 08:59:38 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290443, encodeId=d9bc29044354, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat Feb 24 08:29:01 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290422, encodeId=0a14290422b6, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Feb 24 07:44:04 CST 2018, time=2018-02-24, status=1, ipAttribution=)]
    2018-02-24 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

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