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Circ-Cardiovasc Inte:妊娠与自发性冠状动脉夹层的风险分析

2017-03-19 xing.T MedSci原创

由此可见,妊娠相关的自发性冠状动脉夹层通常与左前降支、左主干和多支血管病变相关,导致射血分数降低、危及生命的母体和胎儿的并发症发病率较高。经皮冠状动脉介入术与低成功率和并发症的高可能性相关,往往需要冠状动脉搭桥手术。因持续性或新发自发性冠状动脉夹层导致的复发性缺血性事件在长期随访中很常见。

由于妊娠相关的自发性冠状动脉夹层较为罕见,有关于它的信息也较为有限。近日,血管领域权威杂志Circulation: Cardiovascular Interventions上发表了一篇研究文章,研究人员回顾了大量的妊娠相关自发性冠状动脉夹层的病例,试图定义该病的临床特点,并提供治疗建议。

研究人员对妊娠相关的自发性冠状动脉夹层病例进行了文献检索,时间为在2000年至2015年之间,共纳入了120例患者;75%为ST段抬高型心肌梗死患者,80%有前壁心肌梗死。左冠状动脉前降支受累占72%,左主干占36%,并有40%的患者存在多支自发性冠状动脉夹层。射血分数下降到40%的病例有44%。只有50%的患者经皮冠状动脉介入治疗成功。由于复杂的解剖结构、血流动力学不稳定或经皮冠状动脉介入治疗失败,44例患者进行冠状动脉旁路移植术。

产妇并发症包括心源性休克(24%),机械支持(28%),紧急经皮冠状动脉介入治疗(28%),紧急冠状动脉旁路手术(27.5%),产妇死亡(4%),胎儿死亡(2.5%)。

在随访了305±111天期间,症状发生率较高,因持续或新发的自发性冠状动脉夹层,5名妇女需要心脏移植或心室辅助装置植入术。

由此可见,妊娠相关的自发性冠状动脉夹层通常与左前降支、左主干和多支血管病变相关,导致射血分数降低、危及生命的母体和胎儿的并发症发病率较高。经皮冠状动脉介入术与低成功率和并发症的高可能性相关,往往需要冠状动脉搭桥手术。因持续性或新发自发性冠状动脉夹层导致的复发性缺血性事件在长期随访中很常见。

原始出处:


Ofer Havakuk, et al. Pregnancy and the Risk of Spontaneous Coronary Artery Dissection An Analysis of 120 Contemporary Cases. Circulation: Cardiovascular Interventions. 2016;9:e004950. https://doi.org/10.1161/CIRCINTERVENTIONS.117.004941

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    2017-03-21 sodoo
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    2017-03-20 医艺依意

    只是学习一下

    0

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    2017-03-19 shaosai

    好好学习,涨知识

    0

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    2017-03-19 1e15b6fem30(暂无匿称)

    很好的学习资料,谢谢了。

    0

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    2017-03-19 1e1b80f0m19(暂无匿称)

    对比分析会有意想不到的收获!

    0

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