NAT MED:大脑神经酰胺水平降低或可抗抑郁

2013-07-04 koo bio360

大脑中神经酰胺（一种体内脂肪酸分子）水平的降低对患病小鼠具有抗抑郁的作用，这是《自然-医学》近日发表的一项研究得出的结论。这项发现意味着开发出一种更有效治疗人类抑郁症的潜在新治疗方法的可能。当神经鞘磷脂经过酶切后，神经酰胺便会释放出来——神经鞘磷脂是一种富集在脑细胞膜内的类脂。Erich Gulbins 等人发现小鼠处在压力状态时，大脑神经酰胺的浓度与无压力的小鼠相比有所增加。一些常用抗抑郁药物比

大脑中神经酰胺（一种体内脂肪酸分子）水平的降低对患病小鼠具有抗抑郁的作用，这是《自然-医学》近日发表的一项研究得出的结论。这项发现意味着开发出一种更有效治疗人类抑郁症的潜在新治疗方法的可能。

当神经鞘磷脂经过酶切后，神经酰胺便会释放出来——神经鞘磷脂是一种富集在脑细胞膜内的类脂。

Erich Gulbins 等人发现小鼠处在压力状态时，大脑神经酰胺的浓度与无压力的小鼠相比有所增加。一些常用抗抑郁药物比如阿米替林和氟西汀等可以让小鼠体内的神经酰胺浓度水平趋于正常，其抑郁行为也有所缓解。

Gulbins 等进一步发现将神经酰胺注射到正常小鼠大脑内或者神经鞘磷脂相关切酶的过度表达均可诱发抑郁行为，而芬地林这种酶抑制剂则具有抗抑郁作用。

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

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2014-05-12 siiner

#脑神经#

69 0
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2013-09-25 yangwen5719

#大脑神经#

73 0
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2013-08-04 liye789132251

#Nat#

75 0
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2013-07-06 wushaoling

#抗抑郁#

86 0
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2013-07-06 xugc

#神经酰胺#

71 0
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2013-07-06 ms3994565386320060

#Med#

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NAT MED:大脑神经酰胺水平降低或可抗抑郁

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