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Crit Care:心脏手术后谵妄的危险因素分析

2016-08-30 Moon 译 MedSci原创

目前对心脏手术后谵妄的危险因素还不能完全的理解。本研究的目的是调查术中病理生理改变和治疗干预措施对术后谵妄风险的影响。 这项回顾性队列研究在一所大学医院的心脏外科ICU中进行,纳入了心脏手术后的2个月期间的患者。使用经验证的评分对谵妄进诊断。使用非参数检验对有或无谵妄患者进行比较,应用逻辑回归分析确定独立危险因素。 在心脏手术后的194例患者中,有50例(26%)在他们的住院期间出现了

目前对心脏手术后谵妄的危险因素还不能完全理解。本研究的目的是调查术中病理生理改变和治疗干预措施对术后谵妄风险的影响。

这项回顾性队列研究在一所大学医院的心脏外科ICU中进行,纳入了心脏手术后的2个月期间的患者。使用经验性评分对谵妄进行诊断。使用非参数检验对有或无谵妄的患者进行比较,应用逻辑回归分析确定独立危险因素。

在心脏手术后的194例患者中,有50例(26%)在其住院期间出现谵妄。

单因素分析显示,有或无谵妄患者间具有显著统计学意义的术中变量为:体外循环时间(184 [72-299] vs 113 (37-717)分钟, p < 0.001)、最低平均动脉压(50 [30-70] vs 55 [30-75] mmHg, p = 0.004)、最低血红蛋白水平(85 [56-133] vs 98 [53-150] g/L, p = 0.005)、最低体温(34.5 [24.4-37.2] vs 35.1 [23.9-37.2] °C, p = 0.035)、最高去甲肾上腺素支持(0.11 [0.00-0.69] vs 0.07 [0.00-0.42] μg/kg/分钟, p = 0.001)、红细胞输注的频率(18 [36 %] vs 26 [18 %], p = 0.018)和血小板输注频率(23 [46 %] vs 24 [17 %], p < 0.001)。

多因素分析显示,只有血小板输注是伴或不伴谵妄的独立危险因素(p < 0.001)。

结果表明,对于接受心脏手术的患者,各种手术中的事件,如输注血小板的频率等,是ICU期间术后谵妄发展的危险因素;不过还需要进一步的研究来解开潜在的基本机制。

原始出处:

Rudiger A,et al.Intra-operative events during cardiac surgery are risk factors for the development of delirium in the ICU.  Crit Care. 2016 August 21;20:264. doi: 10.1186/s13054-016-1445-8.

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    2016-09-25 1e10c84am36(暂无匿称)

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    2016-09-15 doctorJiangchao

    继续关注

    0

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content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 13:29:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108406, encodeId=4a2710840602, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 13:28:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108404, encodeId=137a108404c5, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 13:28:00 CST 2016, time=2016-08-31, status=1, ipAttribution=)]
    2016-09-15 doctorJiangchao

    继续关注

    0

  4. 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  5. 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time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108404, encodeId=137a108404c5, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 13:28:00 CST 2016, time=2016-08-31, status=1, ipAttribution=)]
    2016-08-31 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!!

    0

  6. 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content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 13:29:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108406, encodeId=4a2710840602, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 13:28:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108404, encodeId=137a108404c5, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 13:28:00 CST 2016, time=2016-08-31, status=1, ipAttribution=)]
    2016-08-31 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=134790, encodeId=88be134e900c, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 08:37:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127932, encodeId=a2c212e932d1, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, 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time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108404, encodeId=137a108404c5, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 13:28:00 CST 2016, time=2016-08-31, status=1, ipAttribution=)]
    2016-08-31 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!!

    0

  8. 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time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108404, encodeId=137a108404c5, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Aug 31 13:28:00 CST 2016, time=2016-08-31, status=1, ipAttribution=)]
    2016-08-31 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!!

    0

  9. 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    2016-08-31 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!!

    0

  10. 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    2016-08-31 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!!

    0

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