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Am J Cardiol:转氨酶升高与房颤发病率升高相关

2012-11-16 高晓方译 医学论坛网

     欧美学者的一项研究表明,肝脏转氨酶水平升高与房颤发病率升高相关,但其机制仍有待明确。论文于2012年11月5日在线发表于《美国心脏病学杂志》(Am J Cardiol)。   此项研究共纳入3744例受试者。受试者平均年龄为65±10岁,女性占56.8%,并且入组时均无临床心衰。对标准房颤危险因素进行校正之后,利用Cox比例风险模型评估基线血清转氨酶水平与随访10

  房颤

  欧美学者的一项研究表明,肝脏转氨酶水平升高与房颤发病率升高相关,但其机制仍有待明确。论文于2012年11月5日在线发表于《美国心脏病学杂志》(Am J Cardiol)。

  此项研究共纳入3744例受试者。受试者平均年龄为65±10岁,女性占56.8%,并且入组时均无临床心衰。对标准房颤危险因素进行校正之后,利用Cox比例风险模型评估基线血清转氨酶水平与随访10年间偶发性房颤的相关性。

  结果显示,随访期间共有383例受试者出现房颤。两种转氨酶均与偶发性房颤风险升高显著相关,丙氨酸转氨酶和天冬氨酸转氨酶的危险比分别为1.19和1.12。排除中、重度饮酒者之后转氨酶与房颤的相关性依然保持一致。然而,将丙氨酸转氨酶和天冬氨酸转氨酶添加至房颤已知危险因素之后仅轻度改善了房颤的预测性能。

  链接:

  Relation of Circulating Liver Transaminase Concentrations to Risk of New-Onset Atrial Fibrillation



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