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Diabetes Care:成纤维细胞生长因子23与正常或轻度肾功能受损的2型糖尿病患者死亡率

2019-09-09 xing.T MedSci原创

由此可见,对于肾功能正常或轻度受损的2型糖尿病患者,FGF23与心血管事件和死亡风险增加有关。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在探究成纤维细胞生长因子23(FGF23)是否与肾功能正常或轻度受损的2型糖尿病患者不良预后相关。

研究人员测量了310例2型糖尿病患者的FGF23水平,这些患者估计的肾小球过滤速率≥60mL/min/1.73m2。研究人员通过Cox回归分析了FGF23与全因死亡率和主要不良心血管事件(MACE)之间的相关性。

在随访5.8年(3.3-6.5)期间,47名患者发生MACE,28名患者死亡。FGF23与全因死亡(年龄和性别调整风险比为2.78 [95%CI为1.76-4.40])和MACE(1.67 [1.12-2.49])风险增加相关。在对其他潜在混杂因素进行额外调整后,结果相似,并且在独立队列中可重复出一致的结果。

由此可见,对于肾功能正常或轻度受损的2型糖尿病患者,FGF23与心血管事件和死亡风险增加有关。 

原始出处:


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    2020-05-24 yese
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  9. 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JCEM:1岁幼儿体内的成纤维细胞生长因子23(FGF23)浓度受哪些因素调控?

背景:磷是人体内最丰富的元素之一,体内磷的多以磷酸盐(PO4)形式存在。成人正常血浆PO4浓度介于2.5~4.5mg/dl(0.81-1.45mmol/L),婴儿PO4要高50%,儿童高30%,大概是因为生长需要较高的磷酸盐。成纤维细胞生长因子23(FGF23)在磷酸盐代谢中起着重要的作用,但目前的研究不能充分解释它的调节特征。目的:本研究探讨了在儿童早期时FGF23受哪些因素调控,特别是性别和铁

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