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Clin Nutr:化疗对睾丸癌患者的味觉、嗅觉、食欲、身体成分等有什么影响?

2016-11-13 MedSci MedSci原创

睾丸癌患者(TCPs)经化疗治疗后,可能出现味觉和嗅觉的变化。本研究探讨以顺铂为基础的化疗治疗1年,睾丸癌患者的味觉和嗅觉功能、膳食摄入量、食物偏好和身体成分,在治疗前、中、后时期的变化。 研究纳入21例睾丸癌患者,以及48例对照组参与者。使用味觉带和Sniffin' Sticks方法确定参与者的心理味觉和嗅觉功能。使用问卷调查评估参与者的主观味觉、嗅觉、食欲和饥饿。使用食物频率问卷调查分析

睾丸癌患者(TCPs)经化疗治疗后,可能出现味觉和嗅觉的变化。本研究探讨以顺铂为基础的化疗治疗1年,睾丸癌患者的味觉和嗅觉功能、膳食摄入量、食物偏好和身体成分,在治疗前、中、后时期的变化。

研究纳入21例睾丸癌患者,以及48例对照组参与者。使用味觉带和Sniffin' Sticks方法确定参与者的心理味觉和嗅觉功能。使用问卷调查评估参与者的主观味觉、嗅觉、食欲和饥饿。使用食物频率问卷调查分析饮食摄入量。使用不同口味(甜/咸)和不同脂肪或蛋白质含量的食物图片评估参与者的食物偏好。双能X线吸收法(DEXA)测量身体成分。

基线时,与对照组相比,睾丸癌患者的气味阈值更低(P = 0.045),对高脂甜食的偏好程度更低(P = 0.024)。随着时间的推移,个体内部的心理味觉和嗅觉功能是高度可变的。化疗完成后与基线比较,咸味道的阈值增加(P = 0.006)。每一个化疗周期都会出现短暂的主观味觉、食欲和饥饿感的下降。化疗过程中与基线相比,脂肪量的百分比增加,而瘦体重和骨密度降低(P < 0.05)。

应该在每个化疗周期的第一个星期,制定针对主观味觉障碍的策略。由于睾丸癌患者的身体成分已经在完成化疗后改变,应该在治疗期间就开始进行心血管危险因素的干预。

原始出处:

IJpma I1, Renken RJ2, Gietema JA.et al.Changes in taste and smell function, dietary intake, food preference, and body composition in testicular cancer patients treated with cisplatin-based chemotherapy.Clin Nutr. 2016 Oct 27.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=156581, encodeId=ad901565818f, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Nov 18 11:12:05 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368323, encodeId=967c13683232d, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Tue Nov 15 06:26:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447095, encodeId=190c144e09588, content=<a href='/topic/show?id=975010100260' target=_blank style='color:#2F92EE;'>#食欲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101002, encryptionId=975010100260, topicName=食欲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SpcCrdwMXJSYUAG0eoicES3DbgMdjibhYzPShfjJHlHFdRicDAdug8NtPOdBbaYAuYOd50130Q7aibsD2YyL8YvQ2g/132, createdBy=166d5313584, createdName=yeye5224614, createdTime=Tue Nov 15 06:26:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537406, encodeId=a968153e40681, content=<a href='/topic/show?id=b1f09320892' target=_blank style='color:#2F92EE;'>#身体成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93208, encryptionId=b1f09320892, topicName=身体成分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2ac12863902, createdName=chengjn, createdTime=Tue Nov 15 06:26:00 CST 2016, time=2016-11-15, status=1, ipAttribution=)]
    2016-11-18 李东泽

    这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=156581, encodeId=ad901565818f, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Nov 18 11:12:05 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368323, encodeId=967c13683232d, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Tue Nov 15 06:26:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447095, encodeId=190c144e09588, content=<a href='/topic/show?id=975010100260' target=_blank style='color:#2F92EE;'>#食欲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101002, encryptionId=975010100260, topicName=食欲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SpcCrdwMXJSYUAG0eoicES3DbgMdjibhYzPShfjJHlHFdRicDAdug8NtPOdBbaYAuYOd50130Q7aibsD2YyL8YvQ2g/132, createdBy=166d5313584, createdName=yeye5224614, createdTime=Tue Nov 15 06:26:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537406, encodeId=a968153e40681, content=<a href='/topic/show?id=b1f09320892' target=_blank style='color:#2F92EE;'>#身体成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93208, encryptionId=b1f09320892, topicName=身体成分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2ac12863902, createdName=chengjn, createdTime=Tue Nov 15 06:26:00 CST 2016, time=2016-11-15, status=1, ipAttribution=)]
    2016-11-15 zhangph
  3. [GetPortalCommentsPageByObjectIdResponse(id=156581, encodeId=ad901565818f, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Nov 18 11:12:05 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368323, encodeId=967c13683232d, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Tue Nov 15 06:26:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447095, encodeId=190c144e09588, content=<a href='/topic/show?id=975010100260' target=_blank style='color:#2F92EE;'>#食欲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101002, encryptionId=975010100260, topicName=食欲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SpcCrdwMXJSYUAG0eoicES3DbgMdjibhYzPShfjJHlHFdRicDAdug8NtPOdBbaYAuYOd50130Q7aibsD2YyL8YvQ2g/132, createdBy=166d5313584, createdName=yeye5224614, createdTime=Tue Nov 15 06:26:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537406, encodeId=a968153e40681, content=<a href='/topic/show?id=b1f09320892' target=_blank style='color:#2F92EE;'>#身体成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93208, encryptionId=b1f09320892, topicName=身体成分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2ac12863902, createdName=chengjn, createdTime=Tue Nov 15 06:26:00 CST 2016, time=2016-11-15, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=156581, encodeId=ad901565818f, content=这篇咨询不错哦,值得学习,对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Nov 18 11:12:05 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368323, encodeId=967c13683232d, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Tue Nov 15 06:26:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447095, encodeId=190c144e09588, content=<a href='/topic/show?id=975010100260' target=_blank style='color:#2F92EE;'>#食欲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101002, encryptionId=975010100260, topicName=食欲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SpcCrdwMXJSYUAG0eoicES3DbgMdjibhYzPShfjJHlHFdRicDAdug8NtPOdBbaYAuYOd50130Q7aibsD2YyL8YvQ2g/132, createdBy=166d5313584, createdName=yeye5224614, createdTime=Tue Nov 15 06:26:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537406, encodeId=a968153e40681, content=<a href='/topic/show?id=b1f09320892' target=_blank style='color:#2F92EE;'>#身体成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93208, encryptionId=b1f09320892, topicName=身体成分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2ac12863902, createdName=chengjn, createdTime=Tue Nov 15 06:26:00 CST 2016, time=2016-11-15, status=1, ipAttribution=)]

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