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Blood:老年人确诊癌症前5个月,动脉血栓栓塞风险增高

2019-01-11 MedSci MedSci原创

中心点:在748662位参与医疗保险的人群中,确诊癌症前一年动脉血栓栓塞事件的风险增加69%。动脉血栓栓塞事件的风险于正式诊断癌症前5个月开始增高,并在前一个月达到高峰。摘要:癌症患者动脉血栓栓塞事件的风险升高;但目前还不明确风险是从什么时候开始增加。Babak B. Navi等人对确诊癌症前的动脉血栓栓塞事件风险进行评估。研究人员从数据库中筛选出374331位年满67岁的于2005-2013年间

中心点:

在748662位参与医疗保险的人群中,确诊癌症前一年动脉血栓栓塞事件的风险增加69%。

动脉血栓栓塞事件的风险于正式诊断癌症前5个月开始增高,并在前一个月达到高峰。

摘要:

癌症患者动脉血栓栓塞事件的风险升高;但目前还不明确风险是从什么时候开始增加。Babak B. Navi等人对确诊癌症前的动脉血栓栓塞事件风险进行评估。

研究人员从数据库中筛选出374331位年满67岁的于2005-2013年间确诊的癌症患者(乳腺癌、前列腺癌、结肠癌、膀胱癌、子宫癌、胰腺癌、癌和非霍奇金淋巴瘤)。并选取非癌症患者为对照,与癌症患者一对一匹配。动脉血栓栓塞事件定义为心肌梗死以及缺血性卒中。对比癌症组和非癌症组在确诊癌症前360天内的30天动脉血栓栓塞事件风险。

在癌症确诊前的360-151天,两组的30天动脉血栓栓塞事件风险相近。从癌症确诊前150-1天,癌症患者的30天动脉血栓栓塞事件风险要高于匹配的对照,而且随着癌症确诊时间的临近,风险逐渐增高,并于癌症确诊前1个月达到高峰;在癌症确诊前1个月内,2313位(0.62%)癌症患者诊断出动脉血栓栓塞,而对照组仅413位(0.11%;优势比 5.63;95% CI 5.07-6.25)。

综上所述,老年人确诊癌症前150天,动脉血栓栓塞事件的风险开始增加,并于前30天达到峰值。


原始出处:

Babak B. Navi, et al. Arterial thromboembolic events preceding the diagnosis of cancer in older persons. Blood 2018 :blood-2018-06-860874; doi: https://doi.org/10.1182/blood-2018-06-860874 

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