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SLEEP:褪黑素可改善高血压患者应用β受体阻滞剂相关失眠

2012-11-16 晓静 编译 医学论坛网

  目前,全球有数以百万人群应用β受体阻滞剂。《睡眠》(SLEEP)杂志近期刊登一项研究发现,β受体阻滞剂可能通过抑制夜间褪黑素(melatonin)的产生而导致患者睡眠障碍。美国布莱根妇女医院(BWH)的研究者发现,补充褪黑素可明显改善高血压患者应用β受体阻滞剂相关的睡眠。   研究分析了16例常规应用β受体阻滞剂降低血压的患者。患者每晚在入睡前应用褪黑素或安慰剂治疗。   在进行研究的3周

  目前,全球有数以百万人群应用β受体阻滞剂。《睡眠》(SLEEP)杂志近期刊登一项研究发现,β受体阻滞剂可能通过抑制夜间褪黑素(melatonin)的产生而导致患者睡眠障碍。美国布莱根妇女医院(BWH)的研究者发现,补充褪黑素可明显改善高血压患者应用β受体阻滞剂相关的睡眠。

  研究分析了16例常规应用β受体阻滞剂降低血压的患者。患者每晚在入睡前应用褪黑素或安慰剂治疗。

  在进行研究的3周间,应用褪黑素的患者未出现睡眠相关问题,而另一个组需要辅助睡眠。应用褪黑素的患者在停止应用褪黑素后也没有出现反跳性失眠征象。

  哈佛大学医学院Scheer教授表示,受试者停止服用褪黑素后对其睡眠仍有改善作用。对于正在服用β受体阻滞剂的高血压患者,褪黑素前景光明。除外高血压患者,目前还需更多研究来确定是否因其他疾病而应用β受体阻滞剂的患者也能从褪黑素的补充治疗中获益。

 

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    2013-10-13 zhyy88
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