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Diagn Pathol：Treg/Th17比值可作为预测失代偿性肝硬化的潜在标志物

2020-10-03 MedSci原创 MedSci原创

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最近的研究表明，T细胞介导的细胞免疫机制在乙型肝炎进展为肝硬化的过程中发挥了重要作用，但其基本机制仍不清楚。本研究旨在确定Treg/Th17与乙肝相关肝硬化的关系，研究结果已在线发表于Diagn Pa

最近的研究表明，T细胞介导的细胞免疫机制在乙型肝炎进展为肝硬化的过程中发挥了重要作用，但其基本机制仍不清楚。本研究旨在确定Treg/Th17与乙肝相关肝硬化的关系，研究结果已在线发表于Diagn Pathol。

使用流式细胞仪测定所有参与者外周血中Treg和Th17细胞频率，包括93例乙肝相关肝硬化患者和40例健康人。应用Cox回归模型和受试者工作特征曲线研究Treg/Th17比值对失代偿性肝硬化的预后意义。

 

结果显示，乙型肝炎相关性肝硬化患者存在Treg/Th17失衡，其外周血中Treg细胞减少，Th17细胞增加，Treg/Th17比值下降。Treg和Th17细胞呈负相关。Treg/Th17失衡与乙肝相关肝硬化的临床阶段密切相关。从Cox回归模型来看，病毒载量、Treg频率和Treg/Th17比值是预测失代偿性肝硬化的独立因素。ROC分析显示，Treg/Th17比值是预测失代偿性肝硬化的最佳标志物。

综上所述，该研究结果表明，Treg/Th17失衡参与了乙肝相关肝硬化的发病机制，Treg/Th17比值可作为预测失代偿性肝硬化的潜在标志物。

 

原始出处;

 

Yong-Ting Lan, Zhen-Li Wang, et al., Treg/Th17 imbalance and its clinical significance in patients with hepatitis B-associated liver cirrhosis. Diagn Pathol. 2019 Oct 21;14(1):114. doi: 10.1186/s13000-019-0891-4.

 

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    2020-11-19 yb6560

    #Pathol#

    0

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    2021-08-28 智者为医08

    #DIA#

    0

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    2020-10-24 ms5106640509429053

    #代偿性肝硬化#

    0

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    2020-12-29 hukaixun

    #标志物#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1786402, encodeId=ae241e864022e, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Thu Nov 19 07:44:52 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639622, encodeId=27851639622ad, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Aug 28 07:44:52 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077568, encodeId=722e20e7568a8, content=<a href='/topic/show?id=94c7253e768' target=_blank style='color:#2F92EE;'>#代偿性肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25377, encryptionId=94c7253e768, topicName=代偿性肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Sat Oct 24 17:44:52 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841584, encodeId=ac65184158487, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Dec 29 10:44:52 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413579, encodeId=9af814135e9bf, content=<a href='/topic/show?id=9cd21e364df' target=_blank style='color:#2F92EE;'>#Th17#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17364, encryptionId=9cd21e364df, topicName=Th17)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Oct 05 12:44:52 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477213, encodeId=840514e721335, content=<a href='/topic/show?id=81f91e786ce' target=_blank style='color:#2F92EE;'>#Treg#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17786, encryptionId=81f91e786ce, topicName=Treg)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96827361646, createdName=12498484m48(暂无昵称), createdTime=Mon Oct 05 12:44:52 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502154, encodeId=9306150215465, content=<a href='/topic/show?id=e550442591f' target=_blank style='color:#2F92EE;'>#失代偿性肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44259, encryptionId=e550442591f, topicName=失代偿性肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ecdc9510146, createdName=lizhou0207, createdTime=Mon Oct 05 12:44:52 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046463, encodeId=ef3f1046463a6, content=谢谢！最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Sun Oct 04 00:44:52 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
    2020-10-05 zhaojie88

    #Th17#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1786402, encodeId=ae241e864022e, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Thu Nov 19 07:44:52 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639622, encodeId=27851639622ad, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Aug 28 07:44:52 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077568, encodeId=722e20e7568a8, content=<a href='/topic/show?id=94c7253e768' target=_blank style='color:#2F92EE;'>#代偿性肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25377, encryptionId=94c7253e768, topicName=代偿性肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Sat Oct 24 17:44:52 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841584, encodeId=ac65184158487, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Dec 29 10:44:52 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413579, encodeId=9af814135e9bf, content=<a href='/topic/show?id=9cd21e364df' target=_blank style='color:#2F92EE;'>#Th17#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17364, encryptionId=9cd21e364df, topicName=Th17)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Oct 05 12:44:52 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477213, encodeId=840514e721335, content=<a href='/topic/show?id=81f91e786ce' target=_blank style='color:#2F92EE;'>#Treg#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17786, encryptionId=81f91e786ce, topicName=Treg)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96827361646, createdName=12498484m48(暂无昵称), createdTime=Mon Oct 05 12:44:52 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502154, encodeId=9306150215465, content=<a href='/topic/show?id=e550442591f' target=_blank style='color:#2F92EE;'>#失代偿性肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44259, encryptionId=e550442591f, topicName=失代偿性肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ecdc9510146, createdName=lizhou0207, createdTime=Mon Oct 05 12:44:52 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046463, encodeId=ef3f1046463a6, content=谢谢！最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Sun Oct 04 00:44:52 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
    2020-10-05 12498484m48(暂无昵称)

    #Treg#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1786402, encodeId=ae241e864022e, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Thu Nov 19 07:44:52 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639622, encodeId=27851639622ad, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Aug 28 07:44:52 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077568, encodeId=722e20e7568a8, content=<a href='/topic/show?id=94c7253e768' target=_blank style='color:#2F92EE;'>#代偿性肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25377, encryptionId=94c7253e768, topicName=代偿性肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Sat Oct 24 17:44:52 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841584, encodeId=ac65184158487, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Dec 29 10:44:52 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413579, encodeId=9af814135e9bf, content=<a href='/topic/show?id=9cd21e364df' target=_blank style='color:#2F92EE;'>#Th17#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17364, encryptionId=9cd21e364df, topicName=Th17)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Oct 05 12:44:52 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477213, encodeId=840514e721335, content=<a href='/topic/show?id=81f91e786ce' target=_blank style='color:#2F92EE;'>#Treg#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17786, encryptionId=81f91e786ce, topicName=Treg)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96827361646, createdName=12498484m48(暂无昵称), createdTime=Mon Oct 05 12:44:52 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502154, encodeId=9306150215465, content=<a href='/topic/show?id=e550442591f' target=_blank style='color:#2F92EE;'>#失代偿性肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44259, encryptionId=e550442591f, topicName=失代偿性肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ecdc9510146, createdName=lizhou0207, createdTime=Mon Oct 05 12:44:52 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046463, encodeId=ef3f1046463a6, content=谢谢！最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Sun Oct 04 00:44:52 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
    2020-10-05 lizhou0207

    #失代偿性肝硬化#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1786402, encodeId=ae241e864022e, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Thu Nov 19 07:44:52 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639622, encodeId=27851639622ad, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Aug 28 07:44:52 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077568, encodeId=722e20e7568a8, content=<a href='/topic/show?id=94c7253e768' target=_blank style='color:#2F92EE;'>#代偿性肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25377, encryptionId=94c7253e768, topicName=代偿性肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Sat Oct 24 17:44:52 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841584, encodeId=ac65184158487, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Dec 29 10:44:52 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413579, encodeId=9af814135e9bf, content=<a href='/topic/show?id=9cd21e364df' target=_blank style='color:#2F92EE;'>#Th17#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17364, encryptionId=9cd21e364df, topicName=Th17)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Oct 05 12:44:52 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477213, encodeId=840514e721335, content=<a href='/topic/show?id=81f91e786ce' target=_blank style='color:#2F92EE;'>#Treg#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17786, encryptionId=81f91e786ce, topicName=Treg)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96827361646, createdName=12498484m48(暂无昵称), createdTime=Mon Oct 05 12:44:52 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502154, encodeId=9306150215465, content=<a href='/topic/show?id=e550442591f' target=_blank style='color:#2F92EE;'>#失代偿性肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44259, encryptionId=e550442591f, topicName=失代偿性肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ecdc9510146, createdName=lizhou0207, createdTime=Mon Oct 05 12:44:52 CST 2020, time=2020-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046463, encodeId=ef3f1046463a6, content=谢谢！最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Sun Oct 04 00:44:52 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
    2020-10-04 guging

    谢谢！最新的信息读起来就是收获大

    0

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