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JCAP:阿托西汀用于儿童注意缺陷/多动症状的功效

2015-04-22 范伟译 MedSci原创

最近的研究表明,抑郁和焦虑的严重程度及药物反应与儿童受虐待有关。然而,儿童有受虐待的历史是否能预测注意缺陷/多动症<span lang="EN-US" style="font-family:"Tahoma","sans-serif"; border:none windowtext 1.0pt;mso-border-alt:none windowtex

背景:最近的研究表明,抑郁和焦虑的严重程度及药物反应与儿童受虐待有关。然而,儿童有受虐待的历史是否能预测注意缺陷/多动症(ADHD) 的严重程度和/或药物反应尚不清楚。因此,我们进行了一项回顾性研究,评估受虐待儿童阿托西汀的有效性。

方法: 我们回顾了41例用阿托西汀治疗的儿童。具体来说,我们通过ADHD症状评定量表(ADHD-RS) 测量受虐待和非受虐待在基线和阿托西汀施药8周后的儿童离解关联症状(DAS)和其他症状(OS)。

结果: 在基线,ADHD症状评定量表上显示受虐待的儿童比非受虐待的儿童有更高的总得分(38.7±9.3 vs 30.5±9.4,p = 0.011),以及更高水平的多动/易动症状(17.3±5.8 vs 11.3±6.0,p=0.004),然而注意力不集中的分数在两组之间相似(21.4±4.8 vs 19.2±4.6)。此外,总分和两部分得分两组第8周都有下降。在非受虐待组,离解关联症状(5.5±2.3 vs 3.9±1.7,p < 0.001)和其他症状(25.0±8.1 vs 17.4±6.7,p < 0.001)在阿托西汀治疗后明显下降。然而,受虐待组在阿托西汀治疗后,离解关联症状并没有改变 (5.9±2.3 vs 5.1±1.8),而其他症状显著下降(32.8±7.6 vs 25.7±7.2,p = 0.002)。

结论: 如果离解关联症状是由受虐待儿童创伤性经历造成的,创伤治疗工具而不是药物疗法可能对治疗离解关联症状有用。这些工具可能包括眼动脱敏和眼动重复脱敏,创伤-聚焦认知行为疗法。

原始出处:

Sugimoto A1, Suzuki Y, Endo T, Matsumoto K, Sugiyama T, Someya T. Efficacy of atomoxetine for symptoms of attention-deficit/hyperactivity disorder in children with a history of child abuse. J Child Adolesc Psychopharmacol. 2015 Apr;25(3):269-71.

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    2024-06-12 ms6000001709747194 来自湖北省

    谢谢

    0

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    2015-11-02 smlt2008
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    2015-04-24 lq1767
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