JAHA：孕妇游离无细胞线粒体DNA减少与先兆子痫有关

2022-01-12 MedSci原创 MedSci原创

与孕龄匹配的健康孕妇相比，先兆子痫妇女的循环DNA水平异常，包括ccf-mtDNA浓度和DNA清除机制降低。

先兆子痫是一种常见的多因素妊娠并发症，在妊娠20周后诊断为新发高血压，伴有终末器官损伤。循环无细胞线粒体DNA(ccf-mtDNA)是一种与损伤相关的分子模式，可反映细胞应激反应和组织损伤，但对于ccf-mtDNA在先兆子痫中的作用知之甚少。

近日，心血管疾病领域权威杂志JAHA上发表了一篇研究文章，该研究旨在明确(1)血浆中ccf-mtDNA的绝对浓度和外周血单核细胞中的线粒体DNA含量，以及(2)先兆子痫妇女和健康对照者血液中ccf-mtDNA的转运形式。此外，研究人员使用自举惩罚Logistic回归试图明确循环DNA相关指标（包括ccf-mtDNA和DNA清除机制）异常与先兆子痫临床诊断之间的关联。

与健康对照组相比，先兆子痫女性血浆中ccf-mtDNA的绝对浓度降低（P≤0.02），而外周血单个核细胞中的mtDNA拷贝数在各组之间没有差异（P>0.05）。虽然先兆子痫患者的ccf-mtDNA降低仍然存在，但使用膜裂解缓冲液从血浆中分离DNA导致先兆子痫组的ccf-mtDNA浓度高出1000倍（P=0.0014）和ccf-mtDNA浓度高出430倍（P<0.0001）。

先兆子痫妇女的血浆并不能诱导过表达人TLR-9基因的胚胎肾293细胞中更大的Toll样受体-9诱导的核因子kappa-轻链增强子激活B细胞依赖性反应（P>0.05）。惩罚回归分析表明，与匹配的对照组相比，患有先兆子痫的女性更可能具有较低浓度的ccf-mtDNA以及较高浓度的核DNA和DNaseI。

由此可见，与孕龄匹配的健康孕妇相比，先兆子痫妇女的循环DNA水平异常，包括ccf-mtDNA浓度和DNA清除机制降低。

原始出处：

Spencer C. Cushen,et al.Reduced Maternal Circulating Cell‐Free Mitochondrial DNA Is Associated With the Development of Preeclampsia.JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.021726

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2022-03-31 whmdzju

#线粒体DN#

107 0
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2022-04-25 病毒猎手

#线粒体#

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2022-01-19 D-House

研究哦

75 0
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2022-01-17 D-House

科研无止境

97 0
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2022-01-13 zhaohui6731

#AHA#

70 0
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2022-01-13 jambiya

#线粒体DNA#

100 0
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2022-01-12 ms4000001513304915

学习#学习#

61 0

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