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Lancet Respir Med:COPD患者心血管并发症风险的研究

2015-07-26 MedSci MedSci原创

    慢性阻塞性肺疾病(COPD)是一种全身性炎症性疾病,并增加了患者心血管疾病的风险。该研究的目的是量化心血管疾病,心血管疾病的主要危险因素,以及COPD整体和特定类型之间的关联程度。    研究人员检索了Cochrane,MEDLINE和Embase数据库在1980年1月1日和2015年4月30日间发表的研究报告,对心血管疾病的患病率和COPD患者与匹

慢性阻塞性肺疾病(COPD)是一种全身性炎症性疾病,并增加了患者心血管疾病的风险。该研究的目的是量化心血管疾病,心血管疾病的主要危险因素,以及COPD整体和特定类型之间的关联程度。

研究人员检索了Cochrane,MEDLINE和Embase数据库在1980年1月1日和2015年4月30日间发表的研究报告,对心血管疾病的患病率和COPD患者与匹配的对照或一般市民随机样本及其危险因素。研究人员评估了随机效应荟萃分析。研究人员通过随机效应荟萃回归, jackknife 敏感性分析,漏斗图评估,以及Egger测试研究了异质性和偏差。

研究人员确定了18176个独特的参考文献,荟萃分析中包括29个数据集。与非COPD人群相比,COPD患者更有可能被诊断为心血管疾病(比值比[OR]2.46;95%Cl 2.02-3.00,P<0.0001),其中包括2至5倍风险的缺血性心脏疾病,心律不整,心脏衰竭,肺循环疾病,和动脉疾病。此外,COPD患者被报道的高血压(OR 1.33,95%Cl 1.13-1.56,P=0.0007),糖尿病(1.36,1.21-1.53,P <0.0001],和曾经吸烟(4.25,3.23-5.60,P<0.0001)现象更常见。在整个研究期间COPD与这些心血管疾病的类型和心血管疾病的危险因素之间的关联是一致的和有效的。招募时间,年龄,数据的质量,和COPD的诊断部分解释了异质性。

COPD,心血管疾病,心血管疾病的主要危险因素的并存强调了对筛查策略的迫切需要,来减少与COPD相关的心血管风险。

原始出处:

Dr Wenjia Chen, MPHcorrespondence†email, Jamie Thomas, BSc†, Mohsen Sadatsafavi, PhD, J Mark FitzGerald, MD,Risk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease,Lancet Respiratory Medicine,2015.7.21

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  1. 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GetPortalCommentsPageByObjectIdResponse(id=35114, encodeId=8371351143b, content=期待有更多研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Thu Aug 06 23:13:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488776, encodeId=69511488e76be, content=<a href='/topic/show?id=69675090ca' target=_blank style='color:#2F92EE;'>#COPD患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5090, encryptionId=69675090ca, topicName=COPD患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852e8475198, createdName=gous, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515100, encodeId=b3fb151510065, content=<a href='/topic/show?id=049251e9368' target=_blank style='color:#2F92EE;'>#心血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51793, encryptionId=049251e9368, topicName=心血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a8b10715402, createdName=zywlvao, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545335, encodeId=89a015453359e, content=<a href='/topic/show?id=a803896303f' target=_blank style='color:#2F92EE;'>#血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89630, encryptionId=a803896303f, topicName=血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b67913724176, createdName=ms3892185887221420, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606554, encodeId=539d160655498, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33526, encodeId=8c123352640, content=这是柳叶刀旗下的一个新的子刊,大家一定要关注哦。, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jul 26 19:28:00 CST 2015, time=2015-07-26, status=1, ipAttribution=)]
    2015-08-16 howi
  2. 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createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jul 26 19:28:00 CST 2015, time=2015-07-26, status=1, ipAttribution=)]
    2015-10-12 hlycom3356

    这篇文章写的很好

    0

  3. 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    2015-10-12 hlycom3356

    这篇文章写的很好

    0

  4. 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GetPortalCommentsPageByObjectIdResponse(id=1515100, encodeId=b3fb151510065, content=<a href='/topic/show?id=049251e9368' target=_blank style='color:#2F92EE;'>#心血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51793, encryptionId=049251e9368, topicName=心血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a8b10715402, createdName=zywlvao, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545335, encodeId=89a015453359e, content=<a href='/topic/show?id=a803896303f' target=_blank style='color:#2F92EE;'>#血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89630, encryptionId=a803896303f, topicName=血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b67913724176, createdName=ms3892185887221420, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606554, encodeId=539d160655498, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33526, encodeId=8c123352640, content=这是柳叶刀旗下的一个新的子刊,大家一定要关注哦。, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jul 26 19:28:00 CST 2015, time=2015-07-26, status=1, ipAttribution=)]
    2015-08-01 丁鹏鹏
  5. [GetPortalCommentsPageByObjectIdResponse(id=1828184, encodeId=3a88182818400, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Aug 16 18:43:00 CST 2015, time=2015-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38555, encodeId=3f993855503, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:24:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=1515100, encodeId=b3fb151510065, content=<a href='/topic/show?id=049251e9368' target=_blank style='color:#2F92EE;'>#心血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51793, encryptionId=049251e9368, topicName=心血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a8b10715402, createdName=zywlvao, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545335, encodeId=89a015453359e, content=<a href='/topic/show?id=a803896303f' target=_blank style='color:#2F92EE;'>#血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89630, encryptionId=a803896303f, topicName=血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b67913724176, createdName=ms3892185887221420, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606554, encodeId=539d160655498, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33526, encodeId=8c123352640, content=这是柳叶刀旗下的一个新的子刊,大家一定要关注哦。, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jul 26 19:28:00 CST 2015, time=2015-07-26, status=1, ipAttribution=)]
    2015-08-06 hlycom3356

    期待有更多研究

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1828184, encodeId=3a88182818400, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Aug 16 18:43:00 CST 2015, time=2015-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38555, encodeId=3f993855503, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:24:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=1515100, encodeId=b3fb151510065, content=<a href='/topic/show?id=049251e9368' target=_blank style='color:#2F92EE;'>#心血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51793, encryptionId=049251e9368, topicName=心血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a8b10715402, createdName=zywlvao, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545335, encodeId=89a015453359e, content=<a href='/topic/show?id=a803896303f' target=_blank style='color:#2F92EE;'>#血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89630, encryptionId=a803896303f, topicName=血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b67913724176, createdName=ms3892185887221420, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606554, encodeId=539d160655498, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33526, encodeId=8c123352640, content=这是柳叶刀旗下的一个新的子刊,大家一定要关注哦。, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jul 26 19:28:00 CST 2015, time=2015-07-26, status=1, ipAttribution=)]
    2015-07-28 gous
  7. 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GetPortalCommentsPageByObjectIdResponse(id=1515100, encodeId=b3fb151510065, content=<a href='/topic/show?id=049251e9368' target=_blank style='color:#2F92EE;'>#心血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51793, encryptionId=049251e9368, topicName=心血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a8b10715402, createdName=zywlvao, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545335, encodeId=89a015453359e, content=<a href='/topic/show?id=a803896303f' target=_blank style='color:#2F92EE;'>#血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89630, encryptionId=a803896303f, topicName=血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b67913724176, createdName=ms3892185887221420, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606554, encodeId=539d160655498, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Jul 28 08:43:00 CST 2015, time=2015-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33526, encodeId=8c123352640, content=这是柳叶刀旗下的一个新的子刊,大家一定要关注哦。, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jul 26 19:28:00 CST 2015, time=2015-07-26, status=1, ipAttribution=)]
  8. 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    2015-07-26 lovetcm

    这是柳叶刀旗下的一个新的子刊,大家一定要关注哦。

    0

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