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Diabetologia:HMGA1基因可能增加2型糖尿病发病风险

2012-06-28 陈智 中国医学论坛报

  近日,华中科技大学汪道文教授等的研究显示,HMGA1是一个重要的糖尿病易感基因,其变异与2型糖尿病(T2DM)发病风险之间存在的相关性不仅适用于欧美人群,中国汉族人群同样具有该基因的遗传易感性。相关论文发表于6月的《糖尿病学》 [Diabetologia 2012,55(6):1685]。    ■ 研究者说   华中科技大学同济医学院附属同济医院汪

  近日,华中科技大学汪道文教授等的研究显示,HMGA1是一个重要的糖尿病易感基因,其变异与2型糖尿病(T2DM)发病风险之间存在的相关性不仅适用于欧美人群,中国汉族人群同样具有该基因的遗传易感性。相关论文发表于6月的《糖尿病学》 [Diabetologia 2012,55(6):1685]。 

  ■ 研究者说

  华中科技大学同济医学院附属同济医院汪道文教授:该研究结果显示,HMGA1基因多态性IVS5-13insC的等位基因频率在糖尿病患者中明显高于正常对照组。 校正各种糖尿病传统危险因素后证实,HMGA1基因的变异IVS5-13insC与中国汉族人群2型糖尿病患病风险间存在相关性。然而该变异导致糖尿病发生的具体机制尚未明确。该研究可能为2型糖尿病的早期预防和未来个体化医疗提供新线索。

原始文献:

Liu L, Ding H, Wang HR, Xu YJ, Cui GL, Wang PH, Yuan G, Yu XF, Wang DW.Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals.Diabetologia. 2012 Jun;55(6):1685-8.
 



    

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