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Diabetes Care:升高的TyG指数预测冠状动脉钙化进展

2019-06-11 xing.T 网络

由此可见,TyG指数是CAC进展的独立预测因子。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究旨在调查甘油三酯和血糖(TyG)指数与成年韩国人冠状动脉钙化(CAC)进展之间的关系。 

研究人员评估了1175名受试者的各种心血管危险因素和人体测量学指标,这些受试者以前在医疗保健中心通过多排CT进行至少两次的CAC评估。使用ln(空腹甘油三酯[mg/dL]×空腹血糖[mg/dL]/2)测得TyG指数。CAC进展定义为基线时无CAC人群出现CAC或基线时具有CAC的受试者基线与随访冠状动脉钙化评分(CACS)之差的平方根增加≥2.5单位。

随访4.2年,312名受试者(27%)发生CAC进展。根据TyG指数,受试者分为三组。随着TyG指数增加,随访CACS和CAC进展的发生率显著升高。针对各种危险因素调整的Logistic回归分析显示,当比较最高和最低TyG指数三分位数时,CAC进展的比值比为1.82(95%CI为1.20-2.77;P≤0.01)。

由此可见,TyG指数是CAC进展的独立预测因子。 

原始出处:

Kahui Park,et al.Elevated TyG Index Predicts Progression of Coronary Artery Calcification.Diabetes Care.2019.https://doi.org/10.2337/dc18-1920

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