CEBP：癌症幸存者生活质量或受影响

2012年11月1日--如今对人类来说，战胜癌症只是第一步，在美国，超过1260万癌症幸存者中有三分之一的人群都会存在身体和精神上的问题，这就使得他们的健康状况值得关注，来自威克森林浸信医学中心的研究人员这样说，相关研究成果刊登于国际杂志Cancer Epidemiol Biomarkers & Prevention上。

研究者Kathryn Weaver教授表示，直到现在我们并没有关于美国癌症幸存者生活质量的相关清晰的数据，这些信息可以帮助医生和研究者判断哪些癌症幸存者面临着较长时间的健康问题。另外这也可以帮助我们开发改善癌症幸存者生活质量的疗法。

这项研究中，研究者分析了2010年全国健康调查的数据，这项调查是由CDC和NCI两个机构联合进行的。科学家对1822个癌症幸存者进行了分析鉴别，然后将其与24，804个无癌症病史的健康成年人进行比较分析。结果显示，乳腺癌、前列腺癌、黑色素瘤患者相比健康个体，这些癌症幸存者生活质量与其一样，甚至高于健康个体。

而宫颈癌、血癌以及结直肠癌患者中40%的人群5年的生存率低于25%。研究者表示，大约330万美国癌症幸存者都存在较差的健康状况以及生活质量，几乎有140万人存在较为严重的身心健康问题。

研究者最后表示，对于医生来说必须加强和癌症病人的交流以及完成癌症患者的治疗以及向幸存者的方向转变，在合理的疗法之后必须鉴别出癌症幸存者的症状和问题，比如疼痛、抑郁、认知问题等，这对于改善癌症幸存者的长期健康状况至关重要。

与癌症相关的拓展阅读：

• Onco & Cancer Res：袁增强等Hippo信号通路和癌症及细胞衰老研究获进展
• EBM：以崭新之生物医学造影技术研究癌症发展模式
• Am J Epidemiol：用体质指数判定癌症风险或需重新思考
• Nat Chem Biol：探究O-葡萄糖转移酶在癌症糖尿病等疾病中的作用
• Am J Epidemiol：夜班或增加男性患癌症风险 更多信息请点击：有关癌症更多资讯

Mental and Physical Health–Related Quality of Life among U.S. Cancer Survivors: Population Estimates from the 2010 National Health Interview Survey

Background: Despite extensive data on health-related quality of life (HRQOL) among cancer survivors, we do not yet have an estimate of the percentage of survivors with poor mental and physical HRQOL compared with population norms. HRQOL population means for adult-onset cancer survivors of all ages and across the survivorship trajectory also have not been published. Methods: Survivors (N = 1,822) and adults with no cancer history (N = 24,804) were identified from the 2010 National Health Interview Survey. The PROMIS® Global Health Scale was used to assess HRQOL. Poor HRQOL was defined as 1 SD or more below the PROMIS® population norm. Results: Poor physical and mental HRQOL were reported by 24.5% and 10.1% of survivors, respectively, compared with 10.2% and 5.9% of adults without cancer (both P < 0.0001). This represents a population of approximately 3.3 million and 1.4 million U.S. survivors with poor physical and mental HRQOL. Adjusted mean mental and physical HRQOL scores were similar for breast, prostate, and melanoma survivors compared with adults without cancer. Survivors of cervical, colorectal, hematologic, short-survival, and other cancers had worse physical HRQOL; cervical and short-survival cancer survivors reported worse mental HRQOL. Conclusion: These data elucidate the burden of cancer diagnosis and treatment among U.S. survivors and can be used to monitor the impact of national efforts to improve survivorship care and outcomes. Impact: We present novel data on the number of U.S. survivors with poor HRQOL. Interventions for high-risk groups that can be easily implemented are needed to improve survivor health at a population level. Cancer Epidemiol Biomarkers Prev; 21(11); 1–10. ©2012 AACR.