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Hepatology:慢性非肝硬化非肿瘤性PVT患者静脉曲张情况研究

2016-03-07 Mechront 译 MedSci原创

慢性非肝硬化非肿瘤性门静脉血栓形成(PVT)需要进行的内镜筛查策略和静脉曲张的管理同肝硬化一样。不过这些方式对PVT的有效性仍未知,因此研究者进行了一项研究,探究慢性PVT患者的胃食管静脉曲张情况。研究纳入了178名慢性PVT患者,中位数随访49(1-598)个月,以静脉曲张的发展和增长,以及门脉高压相关出血事件的发生率和结局作为终点。研究数据显示,有27(15%)名患者以静脉曲张出血为最初表现,

慢性非肝硬化非肿瘤性门静脉血栓形成(PVT)需要进行的内镜筛查策略和静脉曲张的管理同肝硬化一样。不过这些方式对PVT的有效性仍未知,因此研究者进行了一项研究,探究慢性PVT患者的胃食管静脉曲张情况。

研究纳入了178名慢性PVT患者,中位数随访49(1-598)个月,以静脉曲张的发展和增长,以及门脉高压相关出血事件的发生率和结局作为终点。

研究数据显示,有27(15%)名患者以静脉曲张出血为最初表现,对余下151名患者进行内镜检查发现:无静脉曲张 52(34%),食管小静脉曲张(SEVs) 28(19%),食管大静脉曲张(LEVs) 60(40%),不伴LEVs的胃静脉曲张(GVs) 11(7%)。腹水、脾肿大是静脉曲张的独立预测因子。无静脉曲张的患者在第1年、第3年和第5年发展为静脉曲张的可能性分别为2%、22%和22%。SEVs患者在第1年、第3年和第5年发展为LEV的可能性分别为13%、40%和54%。初级预防的LEVs患者在第1年、第3年和第5年出血的可能性分别为9%、20%和32%。中位数随访51(8-280)个月的时间里,有9(5%)名患者死亡,其中只有一人死于静脉曲张出血。

研究结果表明,慢性非肝硬化非肿瘤性PVT患者静脉曲张情况与肝硬化患者相似,使用与肝硬化相同的治疗方式可以降低出血和死亡风险。

原始出处:

Noronha Ferreira C, Seijo S,et al.Natural history and management of esophagogastric varices in chronic non-cirrhotic non-tumoral portal vein thrombosis.Hepatology. 2016 Jan 22. doi: 10.1002/hep.28466.


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    2016-03-15 fusion
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    2016-08-13 紫砂壶
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    2016-03-09 1de5fd4am32(暂无匿称)

    ~~~~

    0

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    2016-03-09 gwc384

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