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胰腺癌的发生还与晒太阳有关?

2015-05-08 佚名 生物谷

近日,来自美国加州大学圣地亚哥分校的研究人员在国际学术期刊the Journal of Steroid Biochemistry and Molecular Biology在线发表了一项最新研究进展,他们发现胰腺癌发生率在光照较少的国家发生率最高,这种关联性可能与维生素D的合成有关。 在该项研究中,研究人员对来自107个国家的人群数据进行了分析,并将国家间差异以及饮酒、肥胖和吸烟情况考虑

近日,来自美国加州大学圣地亚哥分校的研究人员在国际学术期刊the Journal of Steroid Biochemistry and Molecular Biology在线发表了一项最新研究进展,他们发现胰腺癌发生率在光照较少的国家发生率最高,这种关联性可能与维生素D的合成有关。
 
在该项研究中,研究人员对来自107个国家的人群数据进行了分析,并将国家间差异以及饮酒、肥胖和吸烟情况考虑在内。结果发现生活在高纬度或云层较厚区域的人,一年中大部分时间都不能够合成维生素D,这可能是导致胰腺癌发生风险高于正常水平的重要原因。同时,生活在赤道附近阳光充足区域的人们其胰腺癌发生率仅是远离赤道区域的人们的六分之一,这表明维生素D的缺陷可能是促进胰腺癌发生风险的重要因素。
 
自然界中含有维生素D的天然食物种类较少,除了从食物中摄取维生素D,人体还需要通过皮肤在阳光下照射下进行维生素D的合成,但隔着窗户在室内进行阳光照射并不能产生维生素D。
 
之前一些研究已经发现血清中的一种维生素D代谢产物与乳腺癌结肠癌发生有关,而这项研究首次提出维生素D缺陷与胰腺癌发生有关。
 
胰腺癌是世界上排名第十二位的常见癌症,每年诊断出大约338,000名病人患有胰腺癌,并且胰腺癌的致死率非常高,该项研究发现胰腺癌的发生可能与光照产生的维生素D水平有关,对于阐述胰腺癌发生的地域差异具有一定意义。

原始出处:


Cedric F. Garland, Raphael E. Cuomo, Edward D. Gorham, Kenneth Zeng, Sharif B. Mohr. Cloud cover-adjusted ultraviolet B irradiance and pancreatic cancer incidence in 172 countries. The Journal of Steroid Biochemistry and Molecular Biology, 2015; DOI: 10.1016/j.jsbmb.2015.04.004

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1951631, encodeId=ec5119516316a, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Sun May 17 11:26:00 CST 2015, time=2015-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33443, encodeId=e387334434d, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Sat Jul 25 03:27:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27727, encodeId=15942e727ae, content=多晒啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Tue Jun 16 01:57:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23031, encodeId=ca8c230315a, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Sat May 09 07:16:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23016, encodeId=9c76230166d, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Fri May 08 22:37:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22957, encodeId=2b902295e5b, content=有道理,,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f0451620298, createdName=CCLJ, createdTime=Fri May 08 21:35:00 CST 2015, time=2015-05-08, status=1, ipAttribution=)]
    2015-05-17 amyloid
  2. [GetPortalCommentsPageByObjectIdResponse(id=1951631, encodeId=ec5119516316a, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Sun May 17 11:26:00 CST 2015, time=2015-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33443, encodeId=e387334434d, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Sat Jul 25 03:27:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27727, encodeId=15942e727ae, content=多晒啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Tue Jun 16 01:57:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23031, encodeId=ca8c230315a, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Sat May 09 07:16:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23016, encodeId=9c76230166d, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Fri May 08 22:37:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22957, encodeId=2b902295e5b, content=有道理,,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f0451620298, createdName=CCLJ, createdTime=Fri May 08 21:35:00 CST 2015, time=2015-05-08, status=1, ipAttribution=)]
    2015-07-25 byzh1990

    懂了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1951631, encodeId=ec5119516316a, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Sun May 17 11:26:00 CST 2015, time=2015-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33443, encodeId=e387334434d, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Sat Jul 25 03:27:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27727, encodeId=15942e727ae, content=多晒啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Tue Jun 16 01:57:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23031, encodeId=ca8c230315a, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Sat May 09 07:16:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23016, encodeId=9c76230166d, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Fri May 08 22:37:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22957, encodeId=2b902295e5b, content=有道理,,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f0451620298, createdName=CCLJ, createdTime=Fri May 08 21:35:00 CST 2015, time=2015-05-08, status=1, ipAttribution=)]
    2015-06-16 1dd82894m82(暂无匿称)

    多晒啊!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1951631, encodeId=ec5119516316a, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Sun May 17 11:26:00 CST 2015, time=2015-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33443, encodeId=e387334434d, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Sat Jul 25 03:27:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27727, encodeId=15942e727ae, content=多晒啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Tue Jun 16 01:57:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23031, encodeId=ca8c230315a, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Sat May 09 07:16:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23016, encodeId=9c76230166d, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Fri May 08 22:37:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22957, encodeId=2b902295e5b, content=有道理,,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f0451620298, createdName=CCLJ, createdTime=Fri May 08 21:35:00 CST 2015, time=2015-05-08, status=1, ipAttribution=)]
    2015-05-09 zhouanxiu

    有用

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1951631, encodeId=ec5119516316a, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Sun May 17 11:26:00 CST 2015, time=2015-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33443, encodeId=e387334434d, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Sat Jul 25 03:27:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27727, encodeId=15942e727ae, content=多晒啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Tue Jun 16 01:57:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23031, encodeId=ca8c230315a, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Sat May 09 07:16:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23016, encodeId=9c76230166d, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Fri May 08 22:37:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22957, encodeId=2b902295e5b, content=有道理,,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f0451620298, createdName=CCLJ, createdTime=Fri May 08 21:35:00 CST 2015, time=2015-05-08, status=1, ipAttribution=)]
    2015-05-08 huaxipanxing

    看看

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1951631, encodeId=ec5119516316a, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Sun May 17 11:26:00 CST 2015, time=2015-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33443, encodeId=e387334434d, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a25c1635554, createdName=byzh1990, createdTime=Sat Jul 25 03:27:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27727, encodeId=15942e727ae, content=多晒啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Tue Jun 16 01:57:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23031, encodeId=ca8c230315a, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Sat May 09 07:16:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23016, encodeId=9c76230166d, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Fri May 08 22:37:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22957, encodeId=2b902295e5b, content=有道理,,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f0451620298, createdName=CCLJ, createdTime=Fri May 08 21:35:00 CST 2015, time=2015-05-08, status=1, ipAttribution=)]
    2015-05-08 CCLJ

    有道理,,,,

    0

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为了完善灯泡这一发明而试图执行成千上万的实验失败后,托马斯·爱迪生曾说过:“我没有失败,一次也没有。我发现了一万种不能成功的方法。”由澳大利亚的研究人员所领导的一项称为个体化分子胰腺癌治疗或IMPaCT试验的胰腺癌临床试验,可以说是与爱迪生所做的是完全相同的东西。在传统来说,该试验可能被视为失败,因为它一直无法招募符合条件的患者。事实上,胰腺癌和其他进展期癌症类型的一个新个性化癌症治疗范式已经

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近日,国际学术期刊nature communication在线发表了美国科学家的一项最新研究进展,他们对109名胰腺导管腺癌(PDA)病人进行了全外显子测序,发现了PDA中的基因突变多样性,并且为发现PDA治疗靶点提供了重要信息。   胰腺导管腺癌是一种预后效果非常差的恶性疾病,需要深入了解该疾病的病因并开发靶向治疗策略。由于PDA肿瘤中存在大量基质细胞和炎症细胞,因此对来自于病

Cell Res:ERK抑制FBW7促进胰腺癌发展

近日,来自复旦大学医学院的研究人员在国际期刊Cell Research 发表了他们的最新研究进展,他们发现磷酸激酶ERK能够对FBW7进行磷酸化促进其降解,这一过程影响了FBW7发挥其肿瘤抑制因子功能,促进了胰腺癌发生。 胰腺导管腺癌(PDAC)是胰腺癌中最常见的一种可怕疾病,其5年生存率不到5%,是所有癌症中致死率最高的一种。由于缺少有效的早期检测方法以及该种癌症初次诊断后的

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胰腺癌由于具有较强的转移特性,而且在肿瘤产生早期缺乏有效的鉴别标志,因此是致死率很高的癌症类型之一。之前的研究发现,胰腺癌细胞侵染性高的本质是一些关键基因(例如KRAS,TP53,SMAD4等)的突变。另外,周围的基质细胞以及一些趋化因子也为肿瘤的扩散提供了帮助。最近,台湾中央研究院的基因组研究中心Wen-Hwa Lee课题组在JEM杂志发表了他们对IL17b调控胰腺癌的研究。 IL-17是

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