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Circulation发布研究:LDL-C维持在新生儿水平(50 mg/dL),可降约1/3的心梗和卒中风险

2016-12-19 卢芳 中国循环杂志

对于有高胆固醇血症的患者而言,国内外指南均建议将低密度脂蛋白胆固醇(LDL-C)降低在100 mg/dL以下,那么如果把LDL-C降低在新生儿水平合适吗? 近期一项发表在Circulation上的研究显示,对于这些患者将LDL-C降低在新生儿水平,也就是低于50 mg/dL,是安全的,而且可降低约1/3的心梗、卒中或致死性心脏病风险。 研究还显示,每降低39 mg/dL的 LDL-C,

对于有高胆固醇血症的患者而言,国内外指南均建议将低密度脂蛋白胆固醇(LDL-C)降低在100 mg/dL以下,那么如果把LDL-C降低在新生儿水平合适吗?

近期一项发表在Circulation上的研究显示,对于这些患者将LDL-C降低在新生儿水平,也就是低于50 mg/dL,是安全的,而且可降低约1/3的心梗、卒中或致死性心脏病风险。

研究还显示,每降低39 mg/dL的 LDL-C,心梗、卒中、心绞痛以及心血管死亡风险降低24%。

这项研究共纳入10项研究中5000例平均年龄为60岁的受试者。绝大数患者均罹患心血管病,且之前均被诊断为高胆固醇血症,平均LDL-C水平为125 mg/dL。其中一部分患者接受他汀治疗,还有超出半数患者接受他汀和阿利库单抗(alirocumab,每隔两周注射一次)的联合治疗。随访时间为3个月~2年不等。

研究者表示,该研究还有待更长期的随访数据。


原始出处:

Kate Wighton. Lowering cholesterol to 'levels of a new-born' cuts heart attack risk. Medicalxpress. December 16, 2016.

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    2016-12-21 zhwj
  3. [GetPortalCommentsPageByObjectIdResponse(id=1281229, encodeId=ab641281229bb, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422543, encodeId=4f9b14225434f, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164344, encodeId=ad231643441f, content=谢谢分享研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG5854E0519E0D81311.jpg, createdBy=3ff51679470, createdName=1039415152, createdTime=Tue Dec 20 11:02:20 CST 2016, time=2016-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164085, encodeId=62d31640858f, content=学习了好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Dec 19 13:52:59 CST 2016, time=2016-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164080, encodeId=b84b164080d2, content=厉害啊!!我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Mon Dec 19 13:34:26 CST 2016, time=2016-12-19, status=1, ipAttribution=)]
    2016-12-20 1039415152

    谢谢分享研究成果

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1281229, encodeId=ab641281229bb, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422543, encodeId=4f9b14225434f, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164344, encodeId=ad231643441f, content=谢谢分享研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG5854E0519E0D81311.jpg, createdBy=3ff51679470, createdName=1039415152, createdTime=Tue Dec 20 11:02:20 CST 2016, time=2016-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164085, encodeId=62d31640858f, content=学习了好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Dec 19 13:52:59 CST 2016, time=2016-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164080, encodeId=b84b164080d2, content=厉害啊!!我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Mon Dec 19 13:34:26 CST 2016, time=2016-12-19, status=1, ipAttribution=)]
    2016-12-19 thlabcde

    学习了好东西

    0

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    2016-12-19 乐奕11

    厉害啊!!我的哥

    0

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